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LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in b...

Henry(Whitney S),Hendrickson(David G),Beca... Oncotarget 0000-00-00

...PIK3CA. Additional expression profiling highlight that LINC00520 is elevated in a subset of human breast carcinomas, wit...

Analytical evaluation for somatic mutation detection in circulating tumor cel...

Cho(Hyungseok),Kim(Jinho),Han(Song-I),Han(... Biomed Microdevices 0000-00-00

...PIK3CA and APC) of MCF7 cells were evaluated in the isolated samples. The results showed that somatic mutations could be...

Clinical implications of routine genomic mutation sequencing in PIK3CA/AKT1 a...

Cejalvo(Juan Miguel),Pérez-Fidalgo(J Aleja... Breast Cancer Res Treat 0000-00-00

...PIK3CA, AKT1, KRAS, NRAS, and BRAF in order to select patients for targeted therapy clinical trials. The genomes of arch...

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy ...

Politz(Oliver),Siegel(Franziska),Bärfacker... Int J Cancer 0000-00-00

...PIK3CA mutant), the MCF7 and HBCx-2 breast cancer models and the AKT mutant driven prostate cancer (LAPC-4) and anal can...

Pathway level alterations rather than mutations in single genes predict respo...

Shi(W),Jiang(T),Nuciforo(P),Hatzis(C),Holm... Ann Oncol 0000-00-00

...PIK3CA [odds ratio (OR) = 0.42, P = 0.0185]. Mutations in 33 of 714 pathways were significantly associated with response...

Mutation profiles in early-stage lung squamous cell carcinoma with clinical f...

Choi(M),Kadara(H),Zhang(J),Cuentas(E P),Ca... Ann Oncol 0000-00-00

...PIK3CA mutations were associated with markedly decreased tumoral PD-L1 expression, LUSCs with PIK3CA mutations exhibited...

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinom...

Kadara(H),Choi(M),Zhang(J),Cuentas(E P),Ca... Ann Oncol 0000-00-00

...PIK3CA mutations were predictive of poor response to adjuvant therapy. Immune marker analysis revealed that LUADs in smo...

TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papilla...

Oh(Eun Ji),Lee(Sohee),Bae(Ja Seong),Kim(Yo... Endocr Pathol 0000-00-00

...PIK3CA mutations. Over a 4-year follow-up period, structurally identifiable bone metastases were persistent, but serial ...

Case-specific potentiation of glioblastoma drugs by pterostilbene.

Schmidt(Linnéa),Baskaran(Sathishkumar),Joh... Oncotarget 0000-00-00

...PIK3CA and a focal deletion of the chromosomal region 1p32. We identify pterostilbene-induced cell cycle arrest, synergi...

Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR ...

Rankin(Andrew),Klempner(Samuel J),Erlich(R... Oncologist 0000-00-00

...PIK3CA, PTEN, EGFR, and ERBB2. We also identified other targetable GA, including novel kinase fusions, receptor tyrosine...

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