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Whaley(RD),Gupta(S),Erickson(LA) Hum Pathol 2026-08-00

...PIK3CA. In this limited series only one patient died of disease. Even so, three were alive with disease at distant metas...

Cheng(X),Zhang(Y),Qian(C),Holdridge(E),Ana... Nat Commun 2026-05-04

...PIK3CA mutation, Trp53 loss, and MYC overexpression. Using this model together with human EC cell lines, patient-derived...

Gou(H),Li(F),Huang(Z),Zheng(J),Guo(Y),Yao(... CNS Neurol Disord Drug Targets 2026-04-24

...Pik3ca. Experimental validation demonstrated that Tet ameliorated neurological deficits and reduced cerebral ischemic da...

Srinivasan(P),Bristow(SL),Mendez(FL),Krins... Cancer Epidemiol Biomarkers... 2026-05-05

...PIK3CA between the EUR and other ancestry groups in both MSI and MSS tumors. Mutational signatures suggested enrichment ...

Yang(Y),Guo(Y),Zhu(M),Dong(Z),Jiang(S),Wen... Discov Oncol 2026-05-05

...PIK3CA. SMARCA4 mutation is an independent adverse prognostic factor in breast cancer (HR = 1.6, p = 0.02), linked to en...

Ermakov(MS),Regauer(S),Kashofer(K) Lab Invest 2026-07-00

...PIK3CA) and 8q alterations (40%; MYC, HEY1, and RAD21). MYC amplifications coincided with an increased fraction of genom...

Jha(A),Gupta(S),Rayamajhi(A),Yadav(S),Timi... Clin Case Rep 2026-05-00

...PIK3CA therapies may expand treatment options.

Yang(Y),Zhu(X),Fang(Y),Li(J),Shao(X),Li(S)... Autophagy 2026-08-00

...PIK3CA as a direct transcriptional target of ESRRA. Mechanistically, ESRRA bind to a specific promoter region within Pik...

Karakoç(E),Koçak(SB),Kişifli Köş(K),Kayhan... Cells 2026-04-15

...PIK3CA mRNA levels, these changes did not parallel the observed suppression of proliferation, suggesting compensatory re...

Valerio(MR),Sambataro(D),Martorana(F),Grec... Curr Oncol 2026-03-31

...PIK3CA/AKT1/PTEN pathway is a way of overcoming resistance. Recently, the oral, selective AKT kinase inhibitor capivaser...