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Improving the Performance of Somatic Mutation Identification by Recovering Ci...

Fu(Yu),Jovelet(Cécile),Filleron(Thomas),Pe... Cancer Res 0000-00-00

...PIK3CA, and TP53 We further showed that cmDetect detected ctDNA in 89% of patients with confirmed mutated cell-free tumo...

Abnormal expression of PTEN and PIK3CA in pemetrexed-resistant human pancreat...

Shi(X),Gu(H T),Lin(S B),Zhang(Y),Yang(J),Q... Genet Mol Res 0000-00-00

...PIK3CA were overexpressed in the pemetrexed-resistant pancreatic cancer cell line. PTEN and PIK3CA were shown to be upre...

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Mod...

Walton(Josephine),Blagih(Julianna),Ennis(D... Cancer Res 0000-00-00

...Pik3ca), low-grade serous carcinoma (Braf), endometrioid (Ctnnb1), or mucinous (Kras) carcinomas. Using CRISPR/Cas9 gene...

Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the p...

van Ginkel(Joost H),de Leng(Wendy W J),de ... Oncotarget 0000-00-00

...PIK3CA, HRAS, CDK4, FBXW7 and RB1. Mutational co-occurrence predominantly existed between TP53 and PIK3CA, TP53 and CDKN...

Mutational profiling of non-small-cell lung cancer patients resistant to firs...

Jin(Ying),Shao(Yang),Shi(Xun),Lou(Guangyua... Oncotarget 0000-00-00

...PIK3CA mutations, were also reported. However, the mechanisms in the remaining patients are still unknown. In this study...

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor...

Dietz(Steffen),Schirmer(Uwe),Mercé(Clément... PLoS One 0000-00-00

...PIK3CA, ALK, and PTEN as well as variants at COSMIC annotated sites in all six patients analyzed. Moreover, cfDNA reveal...

Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developm...

Zhang(Teng),Yao(Yufeng),Wang(Jingjing),Li(... Hum Mol Genet 0000-00-00

...PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for KTS.

Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-ris...

Longo(Thomas),McGinley(Kathleen F),Freedma... Eur Urol 0000-00-00

...PIK3CA were frequently comutated. We identified no association between mutations in specific genes and key clinical outc...

PTEN loss is associated with a poor response to trastuzumab in HER2-overexpre...

Deguchi(Yasunori),Okabe(Hiroshi),Oshima(No... Gastric Cancer 0000-00-00

...PIK3CA mutations, could provide trastuzumab resistance in GEA.,Expression of HER2 and PTEN, and PIK3CA gene mutations we...

Comparative genomic analysis of primary tumors and metastases in breast cance...

Bertucci(François),Finetti(Pascal),Guille(... Oncotarget 0000-00-00

...PIK3CA, TP53) and 460 non-recurrent variants. The tumors/metastases concordance of variants was 75%, higher for recurren...

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