...PIK3CA (8 patients; 18%), KRAS (6 patients; 14%), and TP53 (5 patients; 11%). No other mutation was found in >7% of spec...
...PIK3CA mutation levels were positively correlated with age. However, the PIK3CA H1047R mutant fraction distributions for...
...PIK3CA and TP53 mutations in one of three primary lung tumors and the metachronous metastasis were identified. In conclu...
...PIK3CA-mutated and 20% in PIK3CA wild-type tumors; 95% CI, 17%-56%), including five objective responses. Of eight patien...
...PIK3CA) gene mutations have been reported in fewer than 5% of primary tumors.,We assessed PIK3CA gene mutations in 145 t...
...PIK3CA, FBXW7 and KRAS.,These results demonstrate that targeted sequencing can reliably identify mutations in individual...
...PIK3CA (15%), STK11 (14%), and BRAF (7%). Genomic mutations in the PI3K/Akt/mTOR pathway were commonly found in non-resp...
...PIK3CA and PIK3CG) and another regulatory subunit (PIK3R4). Inhibiting PI3K with GDC-0941 resulted in in vitro antitumor...
...PIK3CA mutations and PTEN loss by immunohistochemistry were infrequently seen.,The addition of PX-866 to cetuximab did n...
We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been t...
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