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Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-d...

Mancini(Maria L),Lien(Evan C),Toker(Alex) Oncotarget 0000-00-00

...PIK3CA, PTEN, and AKT, which lead to excessive and constitutive activation of Akt and downstream signaling that results ...

RAS mutation is a prognostic biomarker in colorectal cancer patients with met...

Osumi(Hiroki),Shinozaki(Eiji),Suenaga(Mits... Int J Cancer 0000-00-00

...PIK3CA mutations were 38.6% (51/132), 3.6% (5/132), 5.1% (7/132), 5.1% (7/132), and 8.7% (12/132), respectively. With a ...

VarDict: a novel and versatile variant caller for next-generation sequencing ...

Lai(Zhongwu),Markovets(Aleksandra),Ahdesma... Nucleic Acids Res 0000-00-00

...PIK3CA and MET in 16% more patients than previously published variant calls. We believe VarDict will greatly facilitate ...

Multiple and bilateral kidney tumors with clear cells of three different hist...

Raspollini(Maria Rosaria),Castiglione(Fran... APMIS 0000-00-00

...PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors.

Aspirin and Colorectal Cancer Prevention and Treatment: Is It for Everyone?

Coyle(Christopher),Cafferty(Fay Helen),Lan... Curr Colorectal Cancer Rep 0000-00-00

...PIK3CA mutation status, expression of cyclo-oxygenase-2 and human leukocyte antigen class I, along with certain germline...

Dynamic changes of driver genes' mutations across clinical stages in nine can...

Li(Xia) Cancer Med 0000-00-00

...PIK3CA in tumor stages. Combinations of one to three driver genes specifically dominated in each cancer. Across the clin...

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citr...

Chen(Yaqing),Qian(Jianchang),He(Qun),Zhao(... Oncotarget 0000-00-00

...PIK3CA-mutant (HER2+/PIK3CAmut) status in breast tumor cell lines. In HER2+/PIK3CAmut cells, mTORC2 controls Ser-455 pho...

Phase I trial evaluating the antiviral agent Cidofovir in combination with ch...

Deutsch(Eric),Haie-Meder(Christine),Bayar(... Oncotarget 0000-00-00

...PIK3CA (n=5; one also had a KRAS mutation), and HRAS (n=1) mutations.,Cidofovir at a dose of 5mg/kg combined with chemor...

Prognostic implications of PIK3CA amplification in curatively resected liposa...

Kim(Joo Hoon),Lee(Jae Seok),Kim(Eo Jin),Pa... Oncotarget 0000-00-00

...PIK3CA mutation. PIK3CA mutations were more frequent in myxoid/round cell and pleomorphic tumors compared with well-diff...

EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile ...

Moon(Ahrim),Chin(Susie),Kim(Hee Kyung),Kwa... Pathology 0000-00-00

...PIK3CA in distal EBD carcinoma and evaluate the association with clinicopathological factors. Ninety cases of distal ext...

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