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TP53 BRCA1 CRISPR single-cell cancer

Dolly(Saoirse O),Wagner(Andrew J),Bendell(... Clin Cancer Res 0000-00-00

...PIK3CA mutant head-and-neck cancer, and three pleural mesotheliomas).,Apitolisib exhibited dose-proportional pharmacokin...

Lasota(Jerzy),Felisiak-Golabek(Anna),Wasag... Mod Pathol 0000-00-00

...PIK3CA being a common mutational target. In this study, the mutational hotspot in the PIK3CA kinase domain encoded by ex...

Ma(Cynthia X),Sanchez(Cesar),Gao(Feng),Cro... Clin Cancer Res 0000-00-00

...PIK3CA mutation.,MK-2206 plus endocrine treatments were tolerable. MK-2206 in combination with anastrozole is being furt...

Kim(Eun Young),Cho(Eun Na),Park(Heae Surng... Cancer Biol Ther 0000-00-00

...PIK3CA c.1633G>A which are possible target of crizotinib, BH3 mimetics, MEK inhibitors, and PI3K-tyrosine kinase inhibit...

Lin(Douglas I) Oncol Lett 0000-00-00

...PIK3CA mutations (48/90 cases) were associated with significantly improved overall survival compared with that of wild-t...

Olasz(Judit),Doleschall(Zoltán),Dunai(Zsuz... Magy Onkol 0000-00-00

...PIK3CA) mutations and loss of phosphatase and tensin homolog (PTEN). The hiperactivated PI3K/AKT signaling can be associ...

Luk(Peter P),Weston(Jared D),Yu(Bing),Seli... Head Neck 0000-00-00

...PIK3CA, and NRAS mutations (22%; cumulative). The 5-year disease-free survival was 36%.,Salivary duct carcinoma demonstr...

Fang(Wen-Liang),Huang(Kuo-Hung),Lan(Yuan-T... Oncotarget 0000-00-00

Mutations in genes involved in the PI3K/AKT pathway and amplifications of the PIK3CA gene in gastric cancer and their as...

Zheng(Jianyong),Li(Yunming),Zhu(Shaojun),L... Oncotarget 0000-00-00

...PIK3CA mutation. Results showed that NDRG4 mRNA expression was decreased in tumor specimens and significantly correlated...

Di Donato(Nataliya),Rump(Andreas),Mirzaa(G... Hum Mutat 0000-00-00

...PIK3CA-related overgrowth spectrum" associated with PIKC3A mutations and PI3K hyperactivation, adding constitutional PIK...

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