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PIK3CA is implicated as an oncogene in ovarian cancer.

Shayesteh(L),Lu(Y),Kuo(W L),Baldocchi(R),G... Nat Genet 1999-02-10

...PIK3CA copy number and PI3-kinase activity makes PIK3CA a candidate oncogene because a broad range of cancer-related fun...

Proliferative defect and embryonic lethality in mice homozygous for a deletio...

Bi(L),Okabe(I),Bernard(D J),Wynshaw-Boris(... J Biol Chem 1999-05-17

...Pik3cadel/del embryos are developmentally delayed at embryonic day (E) 9.5 and die between E9.5 and E10.5. E9. 5 Pik3cad...

Expression analysis of genes at 3q26-q27 involved in frequent amplification i...

Rácz(A),Brass(N),Heckel(D),Pahl(S),Remberg... Eur J Cancer 1999-10-01

...PIK3CA). While five genes were expressed in the majority of the 17 samples of SCC, the gene for the glucose transporter ...

Molecular cloning, cDNA sequence, and chromosomal localization of the human p...

Volinia(S),Hiles(I),Ormondroyd(E),Nizetic(... Genomics 1995-05-18

...PIK3CA), encoding a protein 99% identical to the bovine p110, and of its gene in YAC is described. The chromosomal local...

Comparative proteomic analysis of low stage and high stage endometrioid ovari...

Kim(Hyeyeung),Wu(Rong),Cho(Kathleen R),Tho... Proteomics Clin Appl 0000-00-00

...PIK3CA mutations. The high stage tumors had mutant p53, were usually high grade, and lacked mutations predicted to dereg...

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xen...

Fang(Douglas D),Zhang(Cathy C),Gu(Yin),Jan... PLoS One 0000-00-00

PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide) mutations can help predict the antitumor activity of ph...

Polyunsaturated Fatty Acids Modulate the Association between PIK3CA-KCNMB3 Ge...

Zheng(Ju-Sheng),Arnett(Donna K),Parnell(La... PLoS One 0000-00-00

Neighboring genes PIK3CA and KCNMB3 are both important for insulin signaling and β-cell function, but their associations...

Novel Mutations in Neuroendocrine Carcinoma of the Breast: Possible Therapeut...

Ang(Daphne),Ballard(Morgan),Beadling(Carol... Diagn Mol Pathol 0000-00-00

...PIK3CA exon 9 E542K mutations, 2 of which also harbored point mutations in FGFR family members (FGFR1 P126S, FGFR4 V550M...

Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict...

Yang(Qi),Shao(Yuan),Shi(Jing),Qu(Yiping),W... Clin Biochem 0000-00-00

...PIK3CA amplification in combination with promoter methylation of RASSF1A and PAX6 genes in early diagnosis and prognosis...

'Druggable' alterations detected by Ion Torrent in metastatic colorectal canc...

Fang(Weijia),Radovich(Milan),Zheng(Yulong)... Oncol Lett 0000-00-00

...PIK3CA and TP53 genes, were mutated in at least two samples. Notably, 90% (9/10) of mCRC patients harbored at least one ...

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