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Translating Gastric Cancer Genomics into Targeted Therapy: Mechanistic Insigh...

Shyu(RY),Wang(LK),Tsai(FM) Cells 2026-02-18

...PIK3CA, and MYC), tumor suppressor genes (TP53, CDH1, and ARID1A), and regulators of genome stability and cell architect...

Romanian Consensus Statement for Hormone Receptor-Positive and Human Epiderma...

Median(MD),Antone(NZ),Volovăț(S),Mazilu(L)... Curr Oncol 2026-02-17

...PIK3CA, AKT1/PTEN, ESR1, plus PD-L1 testing in mTNBC); for HR+/HER2- mBC, first-line endocrine therapy plus CDK4/6 inhib...

Clinical and Genetic Landscape of Glioblastoma, IDH-Wildtype With FGFR Gene F...

Kegoya(Y),Otani(Y),Mizuta(R),Ikemachi(R),K... Cancer Sci 2026-05-00

...PIK3CA mutations and had significantly fewer TERT promoter and PTEN mutations, compared with the mutation-negative group...

STK11 mutations and deletions define a distinct subtype of cervical adenocarc...

Robinson(E),Murphy(E),Albanez(A),Tulsyan(S... medRxiv 2026-01-04

...PIK3CA mutations and YAP1 amplification are prevalent cervical cancer drivers. STK11 mutations and deletions co-occur si...

Genetic diagnosis of macrotia in PIK3CA-Related Overgrowth Spectrum (PROS) an...

Chen(L),Hu(X),Li(J),Li(C),Ma(J),He(A),Fu(Y... Braz J Otorhinolaryngol None

PIK3CA-Related Overgrowth Spectrum (PROS) is a highly heterogeneous disease. Facial Infiltrating Lipomatosis (FIL) is a ...

Integrated network pharmacology, molecular docking and metabolomics studies t...

Yang(X),Gao(M),Zhang(J),Chen(F),Yang(L),Li... J Ethnopharmacol 2026-05-10

...PIK3CA are key targets strongly associated with depression, which is consistent with the molecular docking results. Fina...

Primary peritoneal clear cell carcinoma with metastasis mimicking ovarian car...

Kim(NI),Lee(JS),Lee(KH),Kim(SS) J Ovarian Res 2026-02-07

...PIK3CA mutations. No primary ovarian, endometrial, or renal tumor was detected, supporting a diagnosis of primary perito...

Comprehensive profiling of somatic alterations and HRD characteristics in Chi...

Cui(H),Zhu(M),Ling(B),Zhang(L) Am J Cancer Res None

...PIK3CA mutations were significantly more frequent in the Non-Germline and non-gBRCA groups than in the Germline and gBRC...

Molecular interplay of ASNS and the PI3K-AKT-mTOR pathway in CMV and HIV co-i...

Zhang(H),Yuan(S),Ding(S),Bao(H),Chen(W),Ca... PLoS One None

...PIK3CA, MTOR, AKT2, AKT3), while machine learning validated AKT2 as a critical node. ASNS was consistently upregulated 4...

Loss of PIK3CA allows in vitro growth but not in vivo progression of KRAS mut...

Booth(AL),Caso(G),Rosati(B),Jiang(YP),Zong... bioRxiv 2026-02-04

...PIK3CA for tumor growth both in vitro and in vivo. We first generated a "KPA" cell line by genetically deleting Pik3ca f...

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