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miR-3940-5p associated with genetic damage in workers exposed to hexavalent c...

Li(Yang),Li(Ping),Yu(Shanfa),Zhang(Ji),Wan... Toxicol Lett 2014-09-08

...BRCC3 protein levels were statistically associated with miR-3940-5p level respectively (β(std)=-0.31, P=0.010; β(std)=-0...

Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity...

Py(Bénédicte F),Kim(Mi-Sung),Vakifahmetogl... Mol Cell 2013-03-25

...BRCC3-containing BRISC complex. Our results elucidate a regulatory mechanism involving BRCC3-dependent NLRP3 regulation ...

Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gen...

Hibi(Daisuke),Kijima(Aki),Kuroda(Ken),Suzu... J Toxicol Sci 2013-08-01

...Brcc3), cell cycle progression (Cyce1, Ccna2, and Ccnb1), G(2)/M arrest in response to DNA damage (Chek1 and Wee1), and ...

A two-step mechanism for TRF2-mediated chromosome-end protection.

Okamoto(Keiji),Bartocci(Cristina),Ouzounov... Nature 2013-03-26

...BRCC3 and the ubiquitin ligase UBR5, and is sufficient to suppress chromosome end-to-end fusions. This two-step mechanis...

Disease-dependent differently methylated regions (D-DMRs) of DNA are enriched...

Maekawa(Ryo),Yagi(Shintaro),Ohgane(Jun),Ya... J Reprod Dev 2012-03-05

...BRCC3, DMD, GJB1, AP1S2 and PCDH11X) and one hypermethylated locus (HDAC8). Expression of XIST, which is involved in X ...

Expression and DNA methylation changes in human breast epithelial cells ...

Fernandez(Sandra V),Huang(Yong),Snider(Kar... Int J Oncol 2012-08-31

...BRCC3, all of which are genes involved in DNA repair, as well as the downregulation of PDCD5 and BCL2L11 (BIM), both of ...

Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is a...

Miskinyte(Snaigune),Butler(Matthew G),Herv... Am J Hum Genet 2011-08-17

...BRCC3. We also show that brcc3 morphant zebrafish display angiogenesis defects that are rescued by endothelium-specific ...

A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs...

Grey(Finn),Tirabassi(Rebecca),Meyers(Heath... PLoS Pathog 2010-10-27

...BRCC3, EID1, MAPRE2, and CD147, suggesting that miR-US25-1 is targeting genes within a related pathway. Deletion of miR-...

Identification of genes differentially expressed in mouse fetuses from strept...

Sato(Nanako),Sugimura(Yoshihisa),Hayashi(Y... Endocr J 2008-08-18

...Brcc3, Commd3, Ddx1, and SET was confirmed. We also analyzed the expression level of neural tube defect-related genes, a...

Expression of BRCC3, a novel cell cycle regulated molecule, is associated wit...

Boudreau(Howard E),Broustas(Constantinos G... Int J Mol Med 2007-03-19

...BRCC3 siRNA treatment of MDA-MB 231 cells caused decreased expression of BRCC3 and p-ERK. Furthermore, exogenous BRCC3 e...

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