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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncoge...

Kang(Sohye),Bader(Andreas G),Vogt(Peter K) Proc Natl Acad Sci U S A 2005-03-15

...PIK3CA gene of many human tumors suggests an oncogenic role for the mutated enzyme. We have determined the growth-regula...

Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplificatio...

Lee(Sooyong),Choi(Eui-Ju),Jin(Changbae),Ki... Gynecol Oncol 2005-06-21

The aim of this study was to understand the role of PIK3CA and PTEN on the resistance of human ovarian cancer cells to c...

Mutations of PIK3CA in gastric adenocarcinoma.

Li(Vivian Sze Wing),Wong(Chi Wai),Chan(Tsu... BMC Cancer 2005-12-12

...PIK3CA mutations were found. We also examined PIK3CA expression level by extracting data from the previous large-scale g...

Amplification of Cyclin L1 is associated with lymph node metastases in head a...

Sticht(C),Hofele(C),Flechtenmacher(C),Bosc... Br J Cancer 2005-03-24

...PIK3CA, TP73L), tissue microarray analysis was applied on 280 HNSCCs by fluorescence in situ hybridization. Overall freq...

RNA interference: a potential strategy for isoform-specific phosphatidylinosi...

Zhang(Lin),Yang(Nuo),Liang(Shun),Barchetti... Cancer Biol Ther 2005-07-26

...PIK3CA) is the most important isoform in tumorigenesis and possibly, tumor angiogenesis. Several strategies have been de...

Genetic analysis of human glioblastomas using a genomic microarray system.

Suzuki(Tsuyoshi),Maruno(Motohiko),Wada(Kou... Brain Tumor Pathol 2005-03-16

...PIK3CA (43.3%), and EGR2 (43.3%), but deletion of RB1 or TP53 was rarely detected. Chromosomal gains were observed frequ...

Copy number changes of target genes in chromosome 3q25.3-qter of esophageal s...

Yen(Chueh-Chuan),Chen(Yann-Jang),Pan(Chin-... World J Gastroenterol 2005-04-28

...PIK3CA: 8.13 (+/-1.17); EIF4G1: 1.07 (+/-0.05); SST: 3.07 (+/-0.25); TP63: 2.51 (+/-0.22); TFRC: 2.42 (+/-0.19). Four cl...

Gene expression and prognostic significance in ovarian cancer.

Tammela(J),Odunsi(K) Minerva Ginecol 2005-05-09

...PIK3CA, AKT2, K-ras, c-myc, BRCA1, p53, p16, and p27 in ovarian cancer. Additionally, a review of the use of microarray ...

Genetic alterations of phosphoinositide 3-kinase subunit genes in human gliob...

Mizoguchi(Masahiro),Nutt(Catherine L),Moha... Brain Pathol 2005-02-14

...PIK3CA and PIK3CD, and one case showed an extra copy limited to PIK3CA. One glioblastoma exhibited a 9-bp deletion that ...

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular car...

Lee(Jong Woo),Soung(Young Hwa),Kim(Su Youn... Oncogene 2005-03-22

...PIK3CA) gene is somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene as an oncogene ...

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