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Constitutive activation of Akt contributes to the pathogenesis and survival o...

Rudelius(Martina),Pittaluga(Stefania),Nish... Blood 2006-10-05

...PIK3CA mutations were not detected. We conclude that constitutive activation of the PI3K/Akt pathway contributes to the ...

Phosphoinositide 3-kinases as drug targets in cancer.

Stephens(Len),Williams(Roger),Hawkins(Phil... Curr Opin Pharmacol 2006-05-24

...PIK3CA) are present in a variety of cancers. We now know that three of the most frequent mutations in cancer constitutiv...

Epithelial-mesenchymal transition in gastric cancer (Review).

Katoh(Masaru) Int J Oncol 2006-02-03

...PIK3CA, AKT1 genes, up-regulation of WNT2, WNT2B, WNT8B, and down-regulation of SFRP1 lead to EMT in gastric cancer thro...

Cancer-specific mutations in PIK3CA are oncogenic in vivo.

Bader(Andreas G),Kang(Sohye),Vogt(Peter K) Proc Natl Acad Sci U S A 2006-03-21

The PIK3CA gene, coding for the catalytic subunit p110alpha of class IA phosphatidylinositol 3-kinases (PI3Ks), is frequ...

Mutation of the PIK3CA oncogene in human cancers.

Karakas(B),Bachman(K E),Park(B H) Br J Cancer 2006-03-23

...PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human ma...

Genetic factors in ovarian carcinoma.

Li(A J),Karlan(B Y) Curr Oncol Rep 2005-05-18

...PIK3CA. Although no singular gene alteration has been shown to initiate transformation in the ovarian epithelium, elucid...

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2...

Saal(Lao H),Holm(Karolina),Maurer(Matthew)... Cancer Res 2005-05-26

...PIK3CA) occurs frequently in human cancer. We identified PIK3CA mutations in 26% of 342 human breast tumor samples and c...

The prevalence of PIK3CA mutations in gastric and colon cancer.

Velho(Sérgia),Oliveira(Carla),Ferreira(Ana... Eur J Cancer 2005-09-12

...PIK3CA mutations and KRAS or BRAF mutations. PIK3CA mutations in exons 9 and 20 were present in 13.6% and 10.6% of color...

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

Levine(Douglas A),Bogomolniy(Faina),Yee(Ci... Clin Cancer Res 2005-08-29

...PIK3CA gene encodes the p110alpha catalytic subunit of PI3K, and is amplified in some ovarian cancers, whereas the AKT2 ...

Functional analysis of PIK3CA gene mutations in human colorectal cancer.

Ikenoue(Tsuneo),Kanai(Fumihiko),Hikiba(Yoh... Cancer Res 2005-07-28

Mutations in the PIK3CA gene, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), hav...

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