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Effects of ERBB2 amplicon size and genomic alterations of chromosomes 1, 3, a...

Morrison(Larry E),Jewell(Susan S),Usha(Lyd... Genes Chromosomes Cancer 2007-04-18

...PIK3CA, and PTGS2. In 35 patients with ERBB2-amplified metastatic breast cancer, with 40% overall response to trastuzuma...

Somatic sequence alterations in twenty-one genes selected by expression profi...

Chanock(Stephen J),Burdett(Laurie),Yeager(... Breast Cancer Res 2007-05-10

...PIK3CA.,We have extended the paradigm and analyzed 21 genes primarily identified by expression profiling studies, which ...

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

Ikediobi(Ogechi N),Davies(Helen),Bignell(G... Mol Cancer Ther 2007-02-15

...PIK3CA, PTEN, RB1, STK11, TP53, and VHL) of the 24 genes. All lines have at least one mutation among the cancer genes ex...

Activation of p53-dependent growth suppression in human cells by mutations in...

Kim(Jung-Sik),Lee(Carolyn),Bonifant(Challi... Mol Cell Biol 2007-02-05

...PIK3CA, like inactivated PTEN, could activate p53. Retroviral expression of oncogenic human PIK3CA in MCF10A cells led t...

Allelic dilution obscures detection of a biologically significant resistance ...

Engelman(Jeffrey A),Mukohara(Toru),Zejnull... J Clin Invest 2007-01-05

...PIK3CA oncogenic mutant, p110alpha E545K, was sufficient to abrogate gefitinib-induced apoptosis. These findings suggest...

Improved marker combination for detection of de novo genetic variation and ab...

Kann(Lisa),Han(James),Ahlquist(David),Levi... Clin Chem 2007-02-02

...PIK3CA, and CTNNB1, hypermethylated sequences within SMARCA3 and VIM, and a single-base variation within BRAF. We compar...

Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin...

Hashii(Minako),Fukuda(Mitsunori),Nomura(Hi... Biochem Biophys Res Commun 2007-06-05

...PIK3CA were increased in DT cells compared with NIH/3T3 cells. p120-Gap and PIK3CA genes were induced by addition of ser...

Genetic alterations and their relationship in the phosphatidylinositol 3-kina...

Hou(Peng),Liu(Dingxie),Shan(Yuan),Hu(Shuiy... Clin Cancer Res 2007-07-18

...PIK3CA copy gain was associated with increased PIK3CA protein expression. A mutual exclusivity among these genetic alter...

Activated PI3K signaling as an endogenous inducer of p53 in human cancer.

Lee(Carolyn),Kim(Jung-Sik),Waldman(Todd) Cell Cycle 2007-04-12

...PIK3CA causes functional activation of p53 signaling in human cells.(1)ur data suggest that activation of p53 is a fail-...

PTEN and PIK3CA expression is associated with prolonged survival after gefiti...

Endoh(Hideki),Yatabe(Yasushi),Kosaka(Takay... J Thorac Oncol 2007-05-01

...PIK3CA gene. We also evaluated the expression level of EGFR, PIK3CA, and PTEN by real-time reverse transcriptase polymer...

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