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Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell ca...

Fenic(Irina),Steger(Klaus),Gruber(Christin... Oncol Rep 2007-08-16

...PIK3CA hot-spot mutations in exons 9 and 20, the genomic gain and amplification of PIK3CA, the expression of PIK3CA mRNA...

Absolute quantification of four isoforms of the class I phosphoinositide-3-ki...

Nakamura(Hiroyuki),Dan(Shingo),Akashi(Tets... Biol Pharm Bull 2007-07-17

...PIK3CA, -B, -D and -G, respectively. These isoforms show different tissue distribution and some specific and indispensab...

Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cance...

Woenckhaus(Joachim),Steger(Klaus),Sturm(Kl... Virchows Arch 2007-06-19

...PIK3CA, by fluorescence in situ hybridization. PIK3CA amplification was evaluated by quantitative real-time PCR with res...

PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastati...

Vranić(Semir),Bilalović(Nurija),Lee(Lisa M... Hum Pathol 2007-10-29

...PIK3CA, which encodes the catalytic alpha subunit of the phosphoinositide-3-kinase, and (2) PTEN, which encodes phosphat...

Different prognostic roles of mutations in the helical and kinase domains of ...

Barbareschi(Mattia),Buttitta(Fiamma),Felic... Clin Cancer Res 2007-12-27

...PIK3CA mutations are typical of infiltrating lobular carcinomas. In addition, they indicate that PIK3CA mutations in dif...

Endometrial carcinoma: pathology and genetics.

Prat(Jaime),Gallardo(Alberto),Cuatrecasas(... Pathology 2007-06-13

...PIK3CA, K-Ras, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article...

Evidence for functional redundancy of class IA PI3K isoforms in insulin signa...

Chaussade(Claire),Rewcastle(Gordon W),Kend... Biochem J 2007-07-19

...PIK3CA) that plays the predominant role in insulin signalling. We have used isoform-selective inhibitors of class IA PI3...

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth...

Wang(Jing),Kuropatwinski(Karen),Hauser(Jen... Mol Cancer Ther 2007-06-20

...PIK3CA-bearing cells (mutant cells) and wild-type PIK3CA-bearing cells (wild-type cells) under optimal growth conditions...

Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast can...

Hollestelle(Antoinette),Elstrodt(Fons),Nag... Mol Cancer Res 2007-04-24

...PIK3CA, KRAS, HRAS, NRAS, and BRAF genes in a collection of 40 human breast cancer cell lines. We identified a surprisin...

Amplicon profiles in ovarian serous carcinomas.

Nakayama(Kentaro),Nakayama(Naomi),Jinawath... Int J Cancer 2007-06-13

...PIK3CA as well as in novel loci, including 12p13, 8q24, 12p13 and 12q15. Seven amplicons were selected for dual color fl...

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