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TP53 BRCA1 CRISPR single-cell cancer

Ikediobi(Ogechi N),Reimers(Mark),Durinck(S... Mol Cancer Ther 2008-08-22

...PIK3CA, PTEN, STK11, MADH4, TP53, and CDKN2A). That analysis identified an association between mutation in BRAF and the ...

Nosho(Katsuhiko),Kawasaki(Takako),Ohnishi(... Neoplasia 2008-09-02

...PIK3CA mutations are often present in colorectal cancer. Mutant PIK3CA activates AKT signaling, which up-regulates fatty...

Carneiro(Fátima),Oliveira(Carla),Leite(Mar... Semin Diagn Pathol 2008-12-23

...PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets fo...

Hou(Peng),Ji(Meiju),Xing(Mingzhao) Cancer 2008-11-24

...PIK3CA amplification and mutations and ras mutations, are the major cause of aberrant activation of this pathway in thyr...

Zhang(Lin),Huang(Jia),Yang(Nuo),Greshock(J... Clin Cancer Res 2007-12-14

...PIK3CA (23.6%), PIK3CB (27.0%), PIK3CG (25.8%), PIK3R2 (29.2%), PIK3R3 (21.3%), and PIK3C2B (40.4%). Among those, only P...

Park(Ben Ho),Davidson(Nancy E) Cancer Cell 2007-11-20

...PIK3CA, can mediate trastuzumab resistance. This study extends important work of others and forms the rationale for futu...

Berns(Katrien),Horlings(Hugo M),Hennessy(B... Cancer Cell 2007-11-20

...PIK3CA (activator of the same pathway and frequently mutated in breast cancer) also conferred resistance to trastuzumab ...

Guo(Xiao-Ning),Rajput(Ashwani),Rose(Rebecc... Cancer Res 2007-09-25

Mutations in the PIK3CA gene are common in human cancers, including colon cancer. We compared two pairs of colon cancer ...

Pérez-Tenorio(Gizeh),Alkhori(Liza),Olsson(... Clin Cancer Res 2007-10-04

...PIK3CA gene is mutated. These have been proposed as alternative mechanisms, and their clinicalpathology significance is ...

Saal(Lao H),Johansson(Peter),Holm(Karolina... Proc Natl Acad Sci U S A 2007-06-20

...PIK3CA mutations and/or amplification of HER2. This demonstrates that the signature is more sensitive than PTEN IHC for ...

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