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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutati...

Stemke-Hale(Katherine),Gonzalez-Angulo(Ana... Cancer Res 2008-09-08

...PIK3CA, AKT, and PTEN mutations and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in vitro and on...

Rare PIK3CA hotspot mutations in carcinomas of the biliary tract.

Riener(Marc-Oliver),Bawohl(Marion),Clavien... Genes Chromosomes Cancer 2008-08-08

...PIK3CA hotspot mutations using polymerase chain reaction and direct DNA sequencing. PIK3CA missense mutations were found...

PIK3CA exon 20 mutation is independently associated with a poor prognosis in ...

Lai(Yuen-Liang),Mau(Bey-Liing),Cheng(Wen-H... Ann Surg Oncol 2008-04-04

...PIK3CA exon 20 mutations was 2.881 (95% CI, 1.406-5.900; p = 0.0038).,PIK3CA mutations are common in invasive ductal car...

PIK3CA gene mutations and amplifications in uterine cancers, identified by me...

Miyake(Takahito),Yoshino(Kiyoshi),Enomoto(... Cancer Lett 2008-04-14

...PIK3CA gene have been frequently observed in numerous types of human malignancies. Amplification of the PIK3CA gene has ...

Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor...

Yip(Wai Kien),Leong(Vincent Ching Shian),A... Oncol Rep 2008-03-27

...PIK3CA, encoding the p110alpha catalytic subunit of phosphatidylinositol 3-kinase (PI3K), were also determined in 25 of ...

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molec...

Press(Joshua Z),De Luca(Alessandro),Boyd(N... BMC Cancer 2008-03-17

...PIK3CA transcript levels, PIK3CA gene copy number, and BRCA1, p21, p53, and WT-1 immunohistochemistry.,Eighteen (37%) of...

Clinicopathological analysis of colorectal cancers with PIK3CA mutations in M...

Abubaker(J),Bavi(P),Al-Harbi(S),Ibrahim(M)... Oncogene 2008-06-24

...PIK3CA mutational status in a series of 410 Middle Eastern CRC and 13 colon cell lines to study the prevalence of PIK3CA...

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations...

Oda(Katsutoshi),Okada(Jennifer),Timmerman(... Cancer Res 2008-11-26

...PIK3CA. In breast, colon, and endometrial cancers in which the PI3K pathway is activated by a combination of mutant PIK3...

Association of PTEN gene methylation with genetic alterations in the phosphat...

Hou(Peng),Ji(Meiju),Xing(Mingzhao) Cancer 2008-11-24

...PIK3CA amplification and mutations and ras mutations, are the major cause of aberrant activation of this pathway in thyr...

Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia.

Paes(John E),Ringel(Matthew D) Endocrinol Metab Clin North Am 2008-08-18

...PIK3CA). These genetic abnormalities have been particularly associated with follicular thyroid neoplasia and anaplastic ...

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