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TP53 BRCA1 CRISPR single-cell cancer

Vasudevan(Krishna M),Barbie(David A),Davie... Cancer Cell 2009-07-29

...PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase. How...

Siena(Salvatore),Sartore-Bianchi(Andrea),D... J Natl Cancer Inst 2009-10-13

...PIK3CA oncogenes, or inactivation of the PTEN tumor suppressor gene is central to the progression of colorectal cancer. ...

Shen(Qin),Wang(Xusheng),Chen(Ying),Xu(Ling... Parkinsonism Relat Disord 2009-10-12

...Pik3ca, and Ikbkap. These results demonstrate that the genetical genomics approach provides a powerful tool for construc...

Catasus(Lluis),Gallardo(Alberto),Cuatrecas... Mod Pathol 2009-07-15

...PIK3CA mRNA overexpression (45%), and exon 20 PIK3CA mutations (21%). In the mixed endometrioid adenocarcinomas-non-endo...

Sartore-Bianchi(Andrea),Martini(Miriam),Mo... Cancer Res 2009-03-20

...PIK3CA and 32 (29.0%) KRAS mutations. PIK3CA mutations were significantly associated with clinical resistance to panitum...

Lim(Simin),Choong(Lee-Yee),Kuan(Chong Poh)... J Proteome Res 2009-10-08

...PIK3CA, was knocked down. In addition, silencing of MIF diminished the proliferation of EGF-stimulated CA1h cells when c...

De Roock(Wendy),Biesmans(Bart),De Schutter... Mol Diagn Ther 2009-10-02

...PIK3CA gene. Further studies are needed to help integrate the latest findings into clinically useful tools for personali...

Zou(Zu-Quan),Zhang(Xiao-Hong),Wang(Feng),S... Int J Mol Med 2009-08-13

...PIK3CA were more sensitive to PI-103 than A549 cells with wild-type PIK3CA. PI-103 was found to inhibit growth by causin...

Martin-Fernandez(Cristina),Bales(Juliana),... Mol Cancer Res 2009-09-18

...PIK3CA were generated that could be induced with doxycycline to express synchronously a dominant negative subunit of PI3...

Shibata(Tatsuhiro),Kokubu(Akiko),Tsuta(Koj... Cancer Lett 2009-09-04

...PIK3CA gene in three of 13 SCLC cell lines and two of 15 primary SCLCs. By introducing these mutant PIK3CA cDNAs, we est...

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