...PIK3CA together showed efficacy.,Our data indicates that targeting oncogenic NRAS-driven melanomas require decrease in b...
...PIK3CA, CCND1, MYC and MDM2) were studied by a PCR-based semiquantitative approach. C-Kit, cyclin D1 and EGFR protein le...
...PIK3CA in 28 affinity-purified CCCs and CCC cell lines showed a mutation frequency of 46%. Samples with PIK3CA mutations...
...PIK3CA) and for pharmacodynamic changes of Ki67, phospho-S6, cyclin D1, and progesterone receptor (PgR) by immunohistoch...
...PIK3CA gene in three of 13 SCLC cell lines and two of 15 primary SCLCs. By introducing these mutant PIK3CA cDNAs, we est...
...PIK3CA) or gene amplification (PIK3CB). p110alpha RNAi inhibited growth and promoted apoptosis in all tested ER(+) breas...
...PIK3CA mutations included in our assay. We found no correlation between the presence of a PIK3CA mutation and impaired r...
...PIK3CA were more sensitive to PI-103 than A549 cells with wild-type PIK3CA. PI-103 was found to inhibit growth by causin...
...PIK3CA, cyclooxygenase-2, fatty acid synthase (FASN), beta-catenin, microsatellite instability (MSI), CpG island methyla...
...PIK3CA, PTEN and K-Ras.,Our results and earlier reports suggest that AKT1 mutations might be mutually exclusive with oth...
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