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Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal ...

Qian(Chao-Nan),Furge(Kyle A),Knol(Jared),H... Cancer Res 2009-11-23

...PIK3CA (13.6%, n = 22) and loss of heterozygosity at the PTEN locus (25%, n = 8). In contrast, none of the other subtype...

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carci...

Cohen(Yoram),Shalmon(Bruria),Korach(Jacob)... Gynecol Oncol 2009-12-11

The PI3K/AKT pathway is frequently activated in endometrial carcinoma (EC) mainly due to mutations in the PIK3CA and PTE...

Differential enhancement of breast cancer cell motility and metastasis by hel...

Pang(Huan),Flinn(Rory),Patsialou(Antonia),... Cancer Res 2009-12-21

...PIK3CA) are commonly found in human cancers. These mutations lead to increased proliferation and transformation in cultu...

Lapatinib monotherapy in patients with relapsed, advanced, or metastatic brea...

Toi(M),Iwata(H),Fujiwara(Y),Ito(Y),Nakamur... Br J Cancer 2009-12-24

...PIK3CA mutation or low expression of PTEN derived clinical benefit from lapatinib.,Lapatinib monotherapy had shown anti-...

Knockin of mutant PIK3CA activates multiple oncogenic pathways.

Gustin(John P),Karakas(Bedri),Weiss(Michel... Proc Natl Acad Sci U S A 2009-04-06

...PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human bre...

Overexpression of PIK3CA is associated with lymph node metastasis in esophage...

Akagi(Ichiro),Miyashita(Masao),Makino(Hiro... Int J Oncol 2009-09-11

...PIK3CA was found to be amplified in esophageal squamous cell carcinoma (ESCC) tissue. PIK3CA at 3q26, which encodes the ...

Should individual PI3 kinase isoforms be targeted in cancer?

Jia(Shidong),Roberts(Thomas M),Zhao(Jean J... Curr Opin Cell Biol 2009-06-05

...PIK3CA mutations and/or oncogenic RTKs/Ras, whereas p110beta is the major isoform in mediating PTEN-deficient tumorigene...

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like ...

Gallia(Gary L),Tyler(Betty M),Hann(Christi... Mol Cancer Ther 2009-03-24

...PIK3CA mutations. In this study, we screened phosphatidylinositol 3-kinase/Akt small-molecule inhibitors in an isogenic ...

Colorectal cancer expression of peroxisome proliferator-activated receptor ga...

Ogino(Shuji),Shima(Kaori),Baba(Yoshifumi),... Gastroenterology 2009-04-17

...PIK3CA, p53, p21, beta-catenin, LINE-1 hypomethylation, microsatellite instability (MSI), and the CpG island methylation...

Oncogene amplification pattern in adenoid cystic carcinoma of the salivary gl...

Sequeiros-Santiago(Guadalupe),García-Carra... Oncol Rep 2009-08-11

...PIK3CA, CCND1, MYC and MDM2) were studied by a PCR-based semiquantitative approach. C-Kit, cyclin D1 and EGFR protein le...

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