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[Status of components in EGFR-related signal transduction as predictive marke...

Shimodaira(Hideki),Soeda(Hiroshi),Komine(K... Gan To Kagaku Ryoho 2009-08-20

...PIK3CA mutations or loss of PTEN have also been shown to be other molecular markers to predict resistance to anti-EGFR a...

Transitional cell tumors of the ovary: a comparative clinicopathologic, immun...

Cuatrecasas(Miriam),Catasus(Luis),Palacios... Am J Surg Pathol 2009-04-07

...PIK3CA, and p53 genes was also performed. The mean patient age was 58 years (range, 32 to 85 y). Abdominal enlargement a...

PIK3CA mutation occurs in nasopharyngeal carcinoma but does not significantly...

Chou(Chu-Chung),Chou(Ming-Jen),Tzen(Chin-Y... Med Oncol 2009-11-25

This study was aimed to test whether PIK3CA, BRAF and RAS are mutated in nasopharyngeal carcinomas (NPCs) and, if so, to...

A prospective cohort study shows unique epigenetic, genetic, and prognostic f...

Nosho(Katsuhiko),Kure(Shoko),Irahara(Natsu... Gastroenterology 2009-12-03

...PIK3CA mutations; and expression of beta-catenin, p53, p21, p27, cyclin D1, fatty acid synthase, and cyclooxygenase-2.,C...

Prognostic significance and molecular associations of 18q loss of heterozygos...

Ogino(Shuji),Nosho(Katsuhiko),Irahara(Nats... J Clin Oncol 2009-11-04

...PIK3CA, beta-catenin, p53, CpG island methylator phenotype, LINE-1 methylation, and John Cunningham (JC) virus T antigen...

p21 expression in colon cancer and modifying effects of patient age and body ...

Ogino(Shuji),Nosho(Katsuhiko),Shima(Kaori)... Cancer Epidemiol Biomarkers... 2009-12-15

...PIK3CA, LINE-1 hypomethylation, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI). p21 Loss w...

PIK3CA mutation associates with improved outcome in breast cancer.

Kalinsky(Kevin),Jacks(Lindsay M),Heguy(Adr... Clin Cancer Res 2009-12-29

...PIK3CA mutation is identified in 32.5% of breast cancers. PIK3CA mutation significantly associates with older age at dia...

Inhibiting PI3K as a therapeutic strategy against cancer.

Paz-Ares(Luis),Blanco-Aparicio(Carmen),Gar... Clin Transl Oncol 2009-12-11

...PIK3CA, has been found mutated in a variable proportion of tumours of different origin. Furthermore, PI3K has been shown...

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder...

Platt(Fiona M),Hurst(Carolyn D),Taylor(Cla... Clin Cancer Res 2009-12-22

...PIK3CA, PTEN, TSC1, RHEB, and LKB1) and putative upstream regulators (FGFR3 and RAS genes) for mutation, allelic loss, c...

An A13 repeat within the 3'-untranslated region of epidermal growth factor re...

Yuan(Ziqiang),Shin(Joongho),Wilson(Andrew)... Cancer Res 2009-12-03

...PIK3CA/PTEN pathways were sensitive to EGFR inhibition, whereas those harboring mutations in these signaling mediators w...

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