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TP53 BRCA1 CRISPR single-cell cancer

García-Sáenz(Jose A),Sastre(Javier),Díaz-R... Clin Transl Oncol 2010-02-18

...PIK3CA/ PTEN/AKT and JAK/STAT signalling pathways. A battery of biomarkers is needed to select the patients that will be...

Hafner(C),Landthaler(M),Mentzel(T),Vogt(T) Br J Dermatol 2010-09-20

...PIK3CA mutations were analysed by a SNaPshot assay covering five PIK3CA hotspot mutations.,Five STK and two DPN samples ...

Konstantinova(Darina),Kaneva(Radka),Dimitr... DNA Cell Biol 2010-02-12

...PIK3CA gene in 108 consecutive EC tumor samples. PIK3CA mutations were present in 24 of the 108 (22.2%) cases and KRAS m...

Schönleben(Frank),Qiu(Wanglong),Remotti(He... Langenbecks Arch Surg 2009-05-11

Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic-alpha (PIK...

Costa(Angela M),Herrero(Agustín),Fresno(Ma... Clin Endocrinol (Oxf) 2009-08-31

...PIK3CA exons 9 and 20 were also investigated. For comparison with PTC cases, the BRAF and Ras mutational status was eval...

Zhang(Haijun),Liu(Gang),Dziubinski(Michele... Breast Cancer Res Treat 2009-02-04

...PIK3CA genes (wild type and mutant) based on the human mammary epithelial cell MCF10A. We found that nine different PIK3...

Santarpia(Mariacarmela),Altavilla(Giuseppe... Cancer Invest 2009-01-27

Mutations in PIK3CA and alterations of BRCA1 expression are common in breast cancer and have been correlated with altere...

Kang(S),Seo(S S),Chang(H J),Yoo(C W),Park(... Int J Gynecol Cancer 2009-03-09

...PIK3CA mutations. RASSF1A and hMLH1 methylation were not correlated with the presence of PIK3CA mutations. PIK3CA was fr...

Iorns(Elizabeth),Lord(Christopher J),Grigo... PLoS One 2009-10-27

...PIK3CA, silencing of which was selectively lethal to the MCF7 cell line, which harbours an activating oncogenic PIK3CA m...

Pallier(Karine),Houllier(Anne-Marie),Le Co... Mol Carcinog 2009-06-26

...PIK3CA, and TP53. We found PXN polymorphisms including nonsynonymous ones but no PXN amplification and only 1/159 (<1%) ...

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