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TP53 BRCA1 CRISPR single-cell cancer

Turke(Alexa B),Engelman(Jeffrey A) Clin Cancer Res 2010-12-20

...PIK3CA mutation were validated as biomarkers for sensitivity to the single-agent phosphoinositide 3-kinase (PI3K) inhibi...

Dan(Shingo),Okamura(Mutsumi),Seki(Mariko),... Cancer Res 2010-07-22

...PIK3CA mutation and PTEN loss did not. These correlations were confirmed in human tumor xenografts in vivo, consistent w...

Miron(Alexander),Varadi(Maria),Carrasco(Da... Cancer Res 2010-08-24

...PIK3CA have been found in a significant fraction of breast carcinomas, and it has been proposed that mutant PIK3CA plays...

Al-Saffar(Nada M S),Jackson(L Elizabeth),R... Cancer Res 2010-08-09

...PIK3CA mutant HCT116 colon carcinoma cells with PI-103 resulted in a concentration- and time-dependent decrease in phosp...

Halilovic(Ensar),She(Qing-Bai),Ye(Qing),Pa... Cancer Res 2010-10-07

...PIK3CA allele in MEK inhibitor-resistant cells restores MEK pathway sensitivity, and re-expression of mutant PIK3CA rein...

Zhang(Haijun),Chen(Di),Ringler(Jonathan),C... Cancer Res 2010-06-21

...PIK3CA-H1047R and PIK3CA-E545K, whereas neither DSF nor LY294002 alone could significantly retard tumor growth. Finally,...

Barbi(Stefano),Cataldo(Ivana),De Manzoni(G... J Exp Clin Cancer Res 2010-10-22

...PIK3CA mutations implies an important role for PIK3CA in gastric cancer. The lack of association with any clinical-patho...

Boormans(J L),Korsten(H),Ziel-van der Made... Br J Cancer 2010-06-09

...PIK3CA and PIK3R1 was carried out in samples from primary and recurrent prostate tumours.,We show that, in prostate canc...

Lindgren(David),Frigyesi(Attila),Gudjonsso... Cancer Res 2010-05-27

...PIK3CA, KRAS, HRAS, NRAS, TP53, CDKN2A, and TSC1 in 103 of these cases. Hierarchical cluster analysis identified two int...

Tol(Jolien),Dijkstra(Jeroen R),Klomp(Marjo... Eur J Cancer 2010-11-29

...PIK3CA (exon 9 and 20). Tissue microarray's (TMA's) were constructed for the assessment of EGFR and HER2 gene copy numbe...

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