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TP53 BRCA1 CRISPR single-cell cancer

Troxell(Megan L),Levine(Judith),Beadling(C... Mod Pathol 2010-03-03

...PIK3CA (exon 20 >exon 9, 27 cases). Papillomas had more mutations in AKT1 (54%) than in PIK3CA (21%), whereas papillomas...

Rivera(Michael),Ricarte-Filho(Julio),Patel... Hum Pathol 2010-02-19

...PIK3CA, AKT1, and other related genes. Twenty-five cases met the selection criteria. Tumor necrosis was present in 56.0%...

Hayes(Monica Prasad),Ellenson(Lora Hedrick... Gynecol Oncol 2010-02-05

...PIK3CA, which encodes the catalytic p110-alpha subunit of phosphatidylinositol 3-kinase (PI3K). In addition, claudin-3 a...

Board(Ruth E),Wardley(Andrew M),Dixon(J Mi... Breast Cancer Res Treat 2010-06-16

...PIK3CA mutations using Amplification Refractory Mutation System (ARMS()) allele-specific PCR and Scorpion probes. PIK3CA...

Bardelli(Alberto),Siena(Salvatore) J Clin Oncol 2010-03-25

...PIK3CA, and PTEN on response to therapy is discussed. We suggest that CRCs lacking oncogenic alterations in these four g...

Lauring(J),Cosgrove(D P),Fontana(S),Gustin... Oncogene 2010-05-04

...PIK3CA hotspot mutations. These results suggest that mutations in critical genes within the PI3-kinase (PI3K) pathway ar...

Lurkin(Irene),Stoehr(Robert),Hurst(Carolyn... PLoS One 2010-05-20

...PIK3CA genes. We developed two multiplex assays that simultaneously screen 22 nucleotides in the KRAS, NRAS, BRAF and PI...

Sugimoto(Takafumi),Ohta(Miki),Ikenoue(Tsun... Int J Cancer 2010-09-13

...PIK3CA genes and abnormal expression of the p53, beta-catenin and MYC proteins were analyzed using direct DNA sequencing...

Baldus(Stephan E),Schaefer(Karl-L),Engers(... Clin Cancer Res 2010-04-22

...PIK3CA.,Activating mutations were detected in 41% (KRAS), 7% (BRAF), and 21% (PIK3CA) of the primary tumors. By comparin...

Mordant(Pierre),Loriot(Yohann),Leteur(Céli... Mol Cancer Ther 2010-11-10

...PIK3CA, and BRAF mutations, using immunoblotting to evaluate the inhibitors, and MTT and clonogenic assays for effects o...

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