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Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase in...

O'Brien(Carol),Wallin(Jeffrey J),Sampath(D... Clin Cancer Res 2010-12-20

...PIK3CA, amplification of human epidermal growth factor receptor 2, or dual alterations in two pathway components were ex...

NRAS mutations are rare in colorectal cancer.

Irahara(Natsumi),Baba(Yoshifumi),Nosho(Kat... Diagn Mol Pathol 2010-12-06

...PIK3CA, microsatellite instability, and the CpG island methylator phenotype. Finally, we examined whether NRAS mutation ...

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell ...

Jones(Siân),Wang(Tian-Li),Shih(Ie-Ming),Ma... Science 2010-11-02

...PIK3CA, which encodes a subunit of phosphatidylinositol-3 kinase, and KRAS, which encodes a well-known oncoprotein, had ...

Lung adenocarcinoma from East Asian never-smokers is a disease largely define...

Sun(Yihua),Ren(Yan),Fang(Zhaoyuan),Li(Chen... J Clin Oncol 2010-11-08

...PIK3CA, TP53 and LKB1.,Forty-one tumors harbored EGFR mutations, three harbored EML4-ALK fusions, two harbored HER2 inse...

Genetic and epigenetic characteristics of gastric cancers with JC virus T-ant...

Yamaoka(Satoshi),Yamamoto(Hiroyuki),Nosho(... World J Gastroenterol 2010-02-24

...PIK3CA genes were analyzed by polymerase chain reaction (PCR)-single strand conformation polymorphism and DNA sequencing...

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Knowles(Margaret A),Platt(Fiona M),Ross(Re... Cancer Metastasis Rev 2010-03-26

...PIK3CA, PTEN, AKT1 and TSC1 in bladder cancer, some of which are significantly related to tumour phenotype and clinical ...

Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma.

Ismail(Said I),Mahmoud(Ismail S),Msallam(M... Leuk Res 2010-06-07

...PIK3CA gene which encodes the p110 catalytic subunit of PI3K kinase is mutated in many human malignancies. To investigat...

Expression profiling reveals a positive regulation by mPer2 on circadian rhyt...

Luo(Yonglun),Tian(Weiping),Cai(Lun),Wang(Y... Chronobiol Int 2010-03-02

...Pik3ca, and Vav1. The mRNA levels of Ly49C (p < 0.001), Ly49I (p = 0.039), and Nkg2d (p = 0.038) were significantly down...

Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phospha...

Meuillet(Emmanuelle J),Zuohe(Song),Lemos(R... Mol Cancer Ther 2010-06-18

...PIK3CA mutation were the most sensitive, and K-Ras mutant tumors were the least sensitive. Combination studies showed th...

PTGER2 overexpression in colorectal cancer is associated with microsatellite ...

Baba(Yoshifumi),Nosho(Katsuhiko),Shima(Kao... Cancer Epidemiol Biomarkers... 2010-06-14

...PIK3CA, and methylation in LINE-1 by Pyrosequencing; and CTNNB1 (beta-catenin) and TP53 (p53) by immunohistochemistry.,P...

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