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TP53 BRCA1 CRISPR single-cell cancer

Marks(Jenifer L),McLellan(Michael D),Zakow... PLoS One 2010-04-29

...PIK3CA, BRAF, and KRAS. We performed mutational profiling of a large cohort of lung adenocarcinomas to uncover other pot...

Dunlap(Jennifer),Le(Claudia),Shukla(Ariell... Breast Cancer Res Treat 2010-06-16

...PIK3CA exons 7, 9, 20, and AKT1 exon 2. Laser capture micro dissection (LCM) was performed on mutation-positive carcinom...

Kataoka(Y),Mukohara(T),Shimada(H),Saijo(N)... Ann Oncol 2010-05-06

...PIK3CA-mutant cells were more resistant to CL-387,785 than PIK3CA-wild-type cells (mean percentage of control with 1 mic...

Hatta(Mamiko),Matsuzaki(Tomoko),Morioka(Yo... Cell Signal 2010-02-18

...PIK3CA mutants), modify the shape of the quadratic curve. Comparison of these modifications implicated Src in Reck down-...

Jehan(Zeenath),Bavi(Prashant),Sultana(Meha... J Pathol 2010-02-22

...PIK3CA gains (ratio >1.0 but <2.0). Both PIK3CA amplification and gains were associated with high levels of PIK3CA prote...

Psyrri(Amanda),Papageorgiou(Sotirios),Liak... Clin Cancer Res 2010-03-30

...PIK3CA gene copy number. In addition, cases with increased PIK3CA gene copy number had elevated PIK3CA mRNA levels. Furt...

Boelens(Mirjam C),Kok(Klaas),van der Vlies... Lung Cancer 2010-06-08

...PIK3CA, ADAM9, MYC and KRAS. Amplification of 2p15-p16 is a novel finding in SCC. Another novel finding is the homozygou...

Liu(Ta-Jen),Koul(Dimpy),LaFortune(Tiffany)... Mol Cancer Ther 2010-01-19

...PIK3CA, contribute to constitutive activation of the phosphatidylinositol 3-kinase (PI3K) pathway. We investigated the p...

Kong(Dexin),Yamori(Takao) Curr Med Chem 2010-02-04

...PIK3CA encoding PI3Kalpha, as well as loss-of-function mutations of PTEN, have been frequently found in human cancers. T...

López-Knowles(Elena),O'Toole(Sandra A),McN... Int J Cancer 2010-01-22

...PIK3CA mutations (12/168, i.e. 7%), PIK3CA copy number gain (28/209, i.e. 14%), PTEN loss (73/258, i.e. 28%) and AKT act...

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