...PIK3CA) play an important role in tumorigenesis. Using PCR-SSCP, followed by sequencing, we examined the PIK3CA gene ove...
...PIK3CA, which encodes the α-catalytic subunit of PI3K, occur in approximately 30% of breast cancers. These mutations res...
...PIK3CA mutation than in those without one. Lapatinib failed to inhibit AKT phosphorylation in PIK3CA mutant cells, likel...
...PIK3CA gene, whereas others underwent a pronounced epithelial-to-mesenchymal transition. Surprisingly, five resistant tu...
...PIK3CA mutations were found in 39 (20%) carcinomas. Six new mutations were identified. No PIK3CA mutations were found in...
...PIK3CA mutations. Prediction of CH5132799 response on the basis of PIK3CA mutations could enable patient stratification ...
...PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelom...
...PIK3CA(H1047R). Notably, most PIK3CA(H1047R)-driven mammary tumors recurred after PIK3CA(H1047R) inactivation. Genomic a...
...PIK3CA and BECN1. Confirmatory immunohistochemical detection was performed for a group of selected proteins. Particularl...
...PIK3CA(E454K or H1047R) alleles and was present only in ductal and lobular histotypes. Our results, showing that AKT1 mu...
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