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TP53 BRCA1 CRISPR single-cell cancer

Azueta(Ainara),Gatius(Sonia),Matias-Guiu(X... Semin Diagn Pathol 2011-03-10

...PIK3CA, FGFR2 and CTNNB1.

Ikegami(Daisuke),Akiyama(Haruhiko),Suzuki(... Development 2011-05-23

...Pik3ca (p110α) was decreased in Sox9(floxdel/floxdel) mouse chondrocytes. Sox9 binds to the promoter and enhances the tr...

Adams(Jessica R),Xu(Keli),Liu(Jeff C),Agam... Cancer Res 2011-07-11

...Pik3ca alleles can be activated through transgenic expression of Cre recombinase. We mated Pik3ca(H1047R) and Pik3ca(wt)...

Mallon(Robert),Feldberg(Larry R),Lucas(Jud... Clin Cancer Res 2011-10-07

...PIK3CA mutant (E545K)] was particularly sensitive to this effect, with cleaved PARP, an apoptosis marker, induced by 30 ...

Weigelt(B),Warne(P H),Downward(J) Oncogene 2011-09-21

The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in breast cancers due to frequent mutations in PI...

LaBonte(Melissa J),Wilson(Peter M),Fazzone... Cancer Res 2011-07-22

...PIK3CA mutations. Lapatinib and panobinostat exerted concentration-dependent antiproliferative effects in vitro (panobin...

Naguib(Adam),Cooke(James C),Happerfield(Li... BMC Cancer 2011-08-01

The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation...

Kennedy(Alyssa L),Morton(Jennifer P),Manoh... Mol Cell 2011-06-02

...PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the ...

Ogita(Shin),Lorusso(Patricia) Target Oncol 2011-11-21

...PIK3CA mutations, loss of phosphatase and tensin homolog (PTEN), Akt mutations, tuberous sclerosis complex (TSC) mutatio...

Xiao(Hong D),Yamaguchi(Hiroshi),Dias-Santa... J Pathol 2011-09-09

...PIK3CA mutations and TP53, SMAD4, and β-catenin expression were analysed, and the results of molecular and clinicopathol...

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