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A potential role for targeted therapy in a subset of metastasizing adnexal ca...

Dias-Santagata(Dora),Lam(Quynh),Bergethon(... Mod Pathol 2011-10-25

...PIK3CA, and TP53) on primary tumors and corresponding metastases of 14 metastasizing adnexal carcinomas (three apocrine,...

Importance of PI3-kinase pathway in response/resistance to aromatase inhibitors.

Ma(Cynthia X),Crowder(Robert J),Ellis(Matt... Steroids 2011-10-03

...PIK3CA, the alpha catalytic subunit of the class IA PI3K, which renders cells dependent on PI3K pathway signaling, is th...

Genotypic and histological evolution of lung cancers acquiring resistance to ...

Sequist(Lecia V),Waltman(Belinda A),Dias-S... Sci Transl Med 2011-07-14

...PIK3CA gene, whereas others underwent a pronounced epithelial-to-mesenchymal transition. Surprisingly, five resistant tu...

Molecular predictors of response to chemotherapy in colorectal cancer.

Dienstmann(Rodrigo),Vilar(Eduardo),Taberne... Cancer J 2011-07-19

...PIK3CA, or PTEN is under intensive investigation. In addition, status of microsatellite instability and molecular marker...

KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with...

Li(Hong-Tao),Lu(Yuan-Yuan),An(Yan-Xin),Wan... Oncol Rep 2011-08-08

...PIK3CA oncogenes are frequently found in colorectal cancer. The aim of the study was to investigate the molecular occurr...

A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies C...

Li(Hui-Fang),Keeton(Adam),Vitolo(Michele),... J Biomol Screen 2011-08-01

...PIK3CA genes. Preferential killing of PTEN and PIK3CA mutant cells was accompanied by DNA damage, inhibition of DNA synt...

Genetic alterations in oral squamous cell carcinoma progression detected by c...

Cha(Jeong-Dan),Kim(Hyung Jun),Cha(In-Ho) Oral Surg Oral Med Oral Pat... 2011-08-22

...PIK3CA, NLGN1, FGF10, HDAC9, GRM3, DDEF1, EDNRB, CHRDL1, and HTR2C, and the highest deletion frequencies in THRAP3, CTTN...

The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinoma...

Tu(Hsi-Feng),Chang(Kuo-Wei),Chiang(Wei-Fan... Oral Oncol 2011-07-01

PIK3CA and PAK1 are critical genes in the PI3K/AKT/PAK pathway. Amplification and strong expression of PIK3CA and PAK1 w...

Endometrioid carcinoma of the endometrium: pathologic and molecular features.

Azueta(Ainara),Gatius(Sonia),Matias-Guiu(X... Semin Diagn Pathol 2011-03-10

...PIK3CA, FGFR2 and CTNNB1.

Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors o...

Kaji(Eisuke),Kato(Jun),Suzuki(Hideyuki),Ak... J Gastroenterol Hepatol 2011-06-13

...PIK3CA) mutations in 101 LST, including 68 LST-granular type (LST-G) and 33 LST-non-granular type by direct sequencing. ...

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