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TP53 BRCA1 CRISPR single-cell cancer

Brown(James R),Auger(Kurt R) BMC Evol Biol 2011-05-18

...PIK3CA are known to be oncogenic and several inhibitors are in anti-cancer clinical trials. We found conservation of act...

Lubezky(Nir),Ben-Haim(Menahem),Marmor(Sylv... J Gastrointest Surg 2011-07-21

...PIK3CA mutations (low grade, 1/14; invasive, 1/7). K-ras, p53, and PIK3CA mutations present in the invasive cancer were ...

Izycka-Swieszewska(Ewa),Brzeskwiniewicz(Ma... Folia Neuropathol 2011-05-04

...PIK3CA c.1060-17 C>A was significantly more frequent in extra-adrenal tumours. Polymorphism PIK3CA c.1145+54 A>G showed ...

Dedes(Konstantin J),Wetterskog(Daniel),Ash... Nat Rev Clin Oncol 2011-09-01

...PIK3CA and FGFR2) and loss of function of genes related to DNA repair (for example PTEN) may lead to more biology-driven...

Aoyagi(Haruhiko),Iida(Satoru),Uetake(Hiroy... Oncol Rep 2011-05-09

...PIK3CA, respectively, in the EGFR pathway. We used the Methylight method to determine the methylation status of hMLH1, p...

Chen(Hongbo),Mei(Lin),Zhou(Lanzhen),Shen(X... J Neurooncol 2011-12-07

...PIK3CA on PTEN-deficient glioblastoma cells in vitro and in subcutaneous xenografts. Restoration of PTEN or knockdown of...

Yap(Timothy A),Walton(Mike I),Hunter(Lisa-... Mol Cancer Ther 2011-10-14

...PIK3CA-mutant BT474 human breast cancer xenografts, consistent with its pharmacokinetic and pharmacodynamic properties. ...

Growdon(Whitfield B),Roussel(Breton N),Sci... Gynecol Oncol 2011-05-16

...PIK3CA (19%), KRAS (15%), CTNNB1 (4%) and NRAS (2%). Mutation in a single gene was observed in 31% of patient samples, w...

Baba(Yoshifumi),Nosho(Katsuhiko),Shima(Kao... Cancer 2011-05-03

...PIK3CA, KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), LINE-1 methylation, TP53 (...

Spindler(Karen-Lise G),Pallisgaard(Niels),... BMC Cancer 2011-06-21

As supplement to KRAS mutational analysis, BRAF and PIK3CA mutations as well as expression of PTEN may account for addit...

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