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TP53 BRCA1 CRISPR single-cell cancer

Kim(Jung-Sik),Xu(Xuehua),Li(Huifang),Solom... Mol Cell Biol 2011-08-23

...PIK3CA. Mutational analysis of PTEN and pharmacological inhibition of Akt revealed that modulation of Akt phosphorylatio...

Nault(Jean-Charles),Zucman-Rossi(Jessica) Semin Liver Dis 2011-08-23

...PIK3CA or EGFR mutations). Recent progress using global genomic analysis has highlighted the marked genetic heterogeneit...

Ogita(Shin),Lorusso(Patricia) Target Oncol 2011-11-21

...PIK3CA mutations, loss of phosphatase and tensin homolog (PTEN), Akt mutations, tuberous sclerosis complex (TSC) mutatio...

Tanizaki(J),Okamoto(I),Fumita(S),Okamoto(W... Oncogene 2011-12-07

...PIK3CA mutation than in those without one. Lapatinib failed to inhibit AKT phosphorylation in PIK3CA mutant cells, likel...

Morikawa(Teppei),Kuchiba(Aya),Yamauchi(Mai... JAMA 2011-04-28

...PIK3CA, and tumor protein p53.,Colorectal cancer-specific mortality and overall mortality through June 30, 2009.,In obes...

Ji(Meiju),Guan(Haixia),Gao(Cuixia),Shi(Bin... BMC Cancer 2011-09-02

...PIK3CA amplification.,Our data showed highly frequent promoter methylation and PIK3CA amplification in Chinese NSCLC pop...

Naguib(Adam),Cooke(James C),Happerfield(Li... BMC Cancer 2011-08-01

The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation...

Kennedy(Alyssa L),Morton(Jennifer P),Manoh... Mol Cell 2011-06-02

...PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the ...

LaBonte(Melissa J),Wilson(Peter M),Fazzone... Cancer Res 2011-07-22

...PIK3CA mutations. Lapatinib and panobinostat exerted concentration-dependent antiproliferative effects in vitro (panobin...

Sasai(Ken),Sukezane(Taiko),Yanagita(Emmy),... Cancer Res 2011-07-11

...PIK3CA, CYCLIN-D1, or a dominant-negative form of LKB1 in combination with the four genetic alterations above. Besides d...

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