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A drug targeting only p110α can block phosphoinositide 3-kinase signalling an...

Jamieson(Stephen),Flanagan(Jack U),Kolekar... Biochem J 2011-10-06

...PIK3CA and mutations in two distinct regions of the PIK3CA gene. This suggests drugs targeting PI3K, and p110α in partic...

Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lympho...

Zhai(Linzhu),Zhao(Yuanyuan),Ye(Sheng),Huan... Tumour Biol 2011-10-04

...PIK3CA and FOXP1 genes of chromosome 3 occur in MALT lymphoma. However, their associated protein expression has not been...

Hypomethylation of the IGF2 DMR in colorectal tumors, detected by bisulfite p...

Baba(Yoshifumi),Nosho(Katsuhiko),Shima(Kao... Gastroenterology 2011-01-04

...PIK3CA mutations.,Methylation at the IGF2 DMR0 was successfully measured in 1105 (94%) of 1178 samples. Colorectal tumor...

A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolim...

Slomovitz(Brian M),Lu(Karen H),Johnston(Ta... Cancer 2011-02-15

...PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in con...

Cathepsin B expression and survival in colon cancer: implications for molecul...

Chan(Andrew T),Baba(Yoshifumi),Shima(Kaori... Cancer Epidemiol Biomarkers... 2011-02-22

...PIK3CA mutation, LINE-1 methylation, TP53 expression, or PTGS2 (cyclooxygenase-2) expression. Among 123 individuals with...

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-m...

Holstege(Henne),van Beers(Erik),Velds(Arno... BMC Cancer 2011-02-03

...PIK3CA associated 3q gain in human BRCA1-mutated tumors, which occurred in tumors from one species but not in tumors fro...

Mechanisms of resistance to anti-human epidermal growth factor receptor 2 age...

Mukohara(Toru) Cancer Sci 2011-01-18

...PIK3CA mutation, or downregulation of p27; or FCGR3A polymorphisms. In addition, we discuss potential strategies for ove...

Histologic, molecular, and cytogenetic features of ovarian cancers: implicati...

Lalwani(Neeraj),Prasad(Srinivasa R),Vikram... Radiographics 2011-09-22

...PIK3CA genes, respectively. High-grade serous carcinomas, the most common subtype, often manifest with early transcoelom...

The selective class I PI3K inhibitor CH5132799 targets human cancers harborin...

Tanaka(Hiroshi),Yoshida(Miyuki),Tanimura(H... Clin Cancer Res 2011-10-07

...PIK3CA mutations. Prediction of CH5132799 response on the basis of PIK3CA mutations could enable patient stratification ...

Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian can...

Huang(Jia),Zhang(Lin),Greshock(Joel),Colli... Genes Chromosomes Cancer 2011-11-07

...PIK3CA, PIK3CB, and PIK3R4 in these tumors were associated with decreased survival. To confirm these findings at the pro...

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