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Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-medi...

Ehrenschwender(M),Siegmund(D),Wicovsky(A),... Cell Death Differ 2011-01-13

Constitutively active PI3K catalytic subunit alpha (PIK3CA) interfered with apoptosis induction downstream of death rece...

Recent patents and advances in genomic biomarker discovery for colorectal can...

Quyun(Chen),Ye(Zhiyun),Lin(Sheng-Cai),Lin(... Recent Pat DNA Gene Seq 2011-03-01

...PIK3CA for predicting the response to anti-EGFR therapies, a common drug used for CRC treatment; 4) patents on epigeneti...

Clinicopathologic and molecular significance of phospho-Akt expression in ear...

Aleskandarany(Mohammed A),Rakha(Emad A),Ah... Breast Cancer Res Treat 2011-08-16

...PIK3CA and pAkt expression, with substantial proportions being PIK3CA⁻/pAkt⁺ or PIK3CA⁺/pAkt⁻. These four combinatorial ...

Molecular genotyping of papillary thyroid carcinoma follicular variant accord...

Rivera(Michael),Ricarte-Filho(Julio),Knauf... Mod Pathol 2011-01-03

...PIK3CA, AKT1 and other related genes. There was no difference in age, gender, tumor size and angioinvasion between encap...

PI3K as a target for therapy in haematological malignancies.

Khwaja(Asim) Curr Top Microbiol Immunol 2011-01-03

...PIK3CA and PTEN occur at a relatively low frequency in haematological malignancies, activation of PI3K signalling is oft...

HER3 and downstream pathways are involved in colonization of brain metastases...

Da Silva(Leonard),Simpson(Peter T),Smart(C... Breast Cancer Res 2011-03-01

...PIK3CA. This paralleled the frequent activation of AKT and MAPK pathways. In particular, activation of the MAPK pathway ...

Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is ...

Hafner(Christian),Landthaler(Michael),Vogt... Exp Dermatol 2011-01-06

...PIK3CA and AKT1 mutations. PIK3CA hotspot mutations were analysed using a highly sensitive SNaPshot assay, and exon 4 of...

Recent progess in phosphoinositide 3-kinases: oncogenic properties and progno...

Wu(Guojun) Curr Protein Pept Sci 2011-02-28

...PIK3CA mutations identified in human cancers. I also discuss the association of PIK3CA mutations with other genetic mark...

Oncogenic mutations of PIK3CA in human cancers.

Samuels(Yardena),Waldman(Todd) Curr Top Microbiol Immunol 2011-01-03

The involvement of the PIK3CA gene product p110α, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in huma...

PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolut...

Vorkas(Panagiotis A),Poumpouridou(Nikoleta... J Mol Diagn 2011-01-13

...PIK3CA gene that is based on a combination of PCR and HRMA. The PIK3CA HRMA assay was evaluated by performing repeatabil...

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