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High throughput interrogation of somatic mutations in high grade serous cance...

Matulonis(Ursula A),Hirsch(Michelle),Pales... PLoS One 2012-06-08

...PIK3CA. Other mutations found in additional genes were found at lower frequencies (<3%).,Sequenom analysis using OncoMap...

Concordance of predictive markers for EGFR inhibitors in primary tumors and m...

Baas(Jara M),Krens(Lisanne L),Guchelaar(He... Oncologist 2012-01-26

...PIK3CA), and loss of phosphatase and tensin homologue deleted on chromosome ten (PTEN). Therefore, it is unknown whether...

Mechanism of EGER-related cancer drug resistance.

Wei(Xiaona) Anticancer Drugs 2012-04-02

...PIK3CA, PTEN, MEK, and AKT on response to therapy. Analysis of these gene signatures identified reveals general modes of...

Cancer immunology--analysis of host and tumor factors for personalized medicine.

Ogino(Shuji),Galon(Jérôme),Fuchs(Charles S... Nat Rev Clin Oncol 2012-03-22

...PIK3CA mutations, microsatellite instability, LINE-1 methylation, and CpG island methylator phenotype. Since tumor molec...

Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinom...

Cohen(Yoram),Goldenberg-Cohen(Nitza),Shalm... Oral Oncol 2012-01-20

...PIK3CA. Missense mutations of the PIK3CA gene were found in 4 of our cases (10.8%); no correlation has been found with o...

Social Responsiveness Scale-aided analysis of the clinical impact of copy num...

van Daalen(Emma),Kemner(Chantal),Verbeek(N... Neurogenetics 2012-03-30

...PIK3CA, GIRDIN), contactin-based networks of cell communication (CNTN6), and microcephalin (MCPH1) were found not to co-...

The Akt/mammalian target of rapamycin pathway is activated and associated wit...

Setsu(Nokitaka),Yamamoto(Hidetaka),Kohashi... Cancer 2012-04-24

...PIK3CA and AKT1 gene mutation.,Immunohistochemically, phosphorylated forms of Akt, mTOR, S6, and 4E-BP1 were positive in...

The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetic...

Roper(Jatin),Richardson(Michael P),Wang(We... PLoS One 2012-02-10

...PIK3CA wild-type colorectal cancer (CRC).,PIK3CA mutant and wild-type human CRC cell lines were treated in vitro with NV...

Colorectal serrated adenocarcinoma shows a different profile of oncogene muta...

García-Solano(J),Conesa-Zamora(P),Carbonel... Int J Cancer 2012-10-31

...PIK3CA mutations, microsatellite instability (MSI) status and loss of the DNA repair proteins MLH1, MSH2, MSH6 and MGMT ...

PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies...

Janku(Filip),Wheler(Jennifer J),Westin(Sha... J Clin Oncol 2012-05-04

...PIK3CA, KRAS, NRAS, and BRAF mutations. Patients with PIK3CA mutations were treated, whenever feasible, with agents targ...

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