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TP53 BRCA1 CRISPR single-cell cancer

Gu(L),Zhu(B),Liu(C),Wu(X),Zhang(Y),Yin(J),... Oncologist 2026-06-06

...PIK3CA (57.1%), FBXW7 (21.4%), TERT (21.4%), BAP1 (19.0%), and EP300 (16.7%). Tumor mutational burden-associated mutatio...

Mehrotra(M),Chakraborty(S),Saldanha(E),Jos... J Ovarian Res 2026-06-23

...PIK3CA gene. Intriguingly, primary tumor cells expressing p53 mutations-R196Q or R175H, in a PIK3CA non-mutated backgrou...

Ural(Z) CEN Case Rep 2026-06-23

PIK3CA-related overgrowth spectrum (PROS) comprises mosaic gain-of-function variants in PIK3CA that lead to segmental ov...

Jia(M),Liu(F),Li(J),Feng(X),Ma(X),Zhang(R)... Brain Res 2026-10-01

...PIK3CA, providing mechanistic plausibility for the observed pathway inhibition. TCGA‑GBM analysis identified AKT1 as a c...

Popoola(J) Clin Ther 2026-08-00

...PIK3CA-Related Overgrowth Spectrum (PROS) disorders as an illustrative example, we examine how integrating biospecimen r...

Bayat(L),McCabe(M),Cherneykin(S),Mills(NE) Case Rep Oncol None

...PIK3CA and, later, the inhibition of ESR1. Repeat NGS late in her treatment revealed new NRG1 NTRK fusion and KRAS G12C ...

Pankam(J),Lapthanasupkul(P),Kitkumthorn(N)... J Appl Oral Sci None

...PIK3CA)) and their associated protein expressions (phosphorylated extracellular signal-regulated kinase 1 and 2 (p-ERK1/...

Li(B),Sun(Y) Hum Cell 2026-06-24

...PIK3CA and inhibit ferroptosis. Overexpression of KAT6A or PIK3CA alleviateS the promoting effect of TRERNA1 knockdown o...

Le(HT),Nghi(NB),My(VD),Vu(HA),Thanh(MC),Tr... Biochem Biophys Res Commun 2026-09-03

...PIK3CA variant. Our study expands the current understanding of PIK3CA-driven oncogenic diversity beyond canonical hotspo...

Fu(C),Wang(C) Discov Oncol 2026-06-24

...PIK3CA mutations. Differential expression analysis indicated that this immune exclusion is structurally maintained by en...

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