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Highly sensitive profiling of CD44+/CD24- breast cancer stem cells by combini...

Hardt(Olaf),Wild(Stefan),Oerlecke(Ilka),Ho... Cancer Lett 2012-11-07

...PIK3CA, PIK3R1 and PIK3R2. This suggests that, in CSCs of ERα-positive breast cancer, the PI3K pathway which is involved...

Identification of enriched driver gene alterations in subgroups of non-small ...

An(She-Juan),Chen(Zhi-Hong),Su(Jian),Zhang... PLoS One 2012-11-27

...PIK3CA (5.2%), c-Met (4.8%), KRAS (4.5%), STK11 (2.7%), and BRAF (1.9%). The three most frequently altered genes in a su...

Biologic therapy in head and neck cancer: a road with hurdles.

Specenier(Pol),Vermorken(Jan B) ISRN Oncol 2012-08-23

...PIK3CA).

Detection of kinase amplifications in gastric cancer archives using fluoresce...

Kiyose(Shin-ichiro),Nagura(Kiyoko),Tao(Hon... Pathol Int 2012-11-19

...PIK3CA, MET, PTK7, ACK1, STK15, SRC, and HCK showed detectable amplifications in paraffin-embedded tissue in 2.83% to 13...

Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancer...

Gulhati(Pat),Zaytseva(Yekaterina Y),Valent... Carcinogenesis 2012-10-31

...PIK3CA mutations are partially sensitive to either rapamycin or sorafenib monotherapy, but highly sensitive to combinati...

Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated i...

Xiong(Donghai),Li(Guangming),Li(Kezhen),Xu... Carcinogenesis 2012-10-31

...PIK3CA, and ROS1), this study revealed "novel" genes not previously implicated in NSCLC. Especially, matrix-remodeling a...

KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome ...

Garrido-Laguna(Ignacio),Hong(David S),Jank... PLoS One 2012-09-17

...PIK3CA mutations were marginally correlated with mucinous tumors (p = 0.05). In the univariate analysis, KRAS and PIK3CA...

Genome haploidisation with chromosome 7 retention in oncocytic follicular thy...

Corver(Willem E),Ruano(Dina),Weijers(Karin... PLoS One 2012-10-11

...PIK3CA/AKT and MAPK pathways.,All FTC-OVs showed a very distinct pattern of genomic alterations. Ten out of 10 FTC-OV ca...

High accuracy mutation detection in leukemia on a selected panel of cancer ge...

Kalender Atak(Zeynep),De Keersmaecker(Kim)... PLoS One 2012-10-11

...PIK3CA, and PTEN. Interestingly, we also found mutations in several cancer genes that had not been linked to T-ALL befor...

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a...

Rivière(Jean-Baptiste),Mirzaa(Ghayda M),O'... Nat Genet 2012-10-09

...PIK3CA in 23 individuals with MCAP and 1 with MPPH. Our data highlight the central role of PI3K-AKT signaling in vascula...

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