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TP53 BRCA1 CRISPR single-cell cancer

Burke(John E),Perisic(Olga),Masson(Glenn R... Proc Natl Acad Sci U S A 2012-12-10

The p110α catalytic subunit (PIK3CA) is one of the most frequently mutated genes in cancer. We have examined the activat...

Vijayalakshmi(R),Krishnamurthy(Arvind) Indian J Surg Oncol 2012-09-06

...PIK3CA, AKT, BRAF, MAP2K1, MET mutations and amplifications along with the well established EGFR and KRAS mutations are ...

Specenier(Pol),Vermorken(Jan B) ISRN Oncol 2012-08-23

...PIK3CA).

Hardt(Olaf),Wild(Stefan),Oerlecke(Ilka),Ho... Cancer Lett 2012-11-07

...PIK3CA, PIK3R1 and PIK3R2. This suggests that, in CSCs of ERα-positive breast cancer, the PI3K pathway which is involved...

An(She-Juan),Chen(Zhi-Hong),Su(Jian),Zhang... PLoS One 2012-11-27

...PIK3CA (5.2%), c-Met (4.8%), KRAS (4.5%), STK11 (2.7%), and BRAF (1.9%). The three most frequently altered genes in a su...

Lindhurst(Marjorie J),Parker(Victoria E R)... Nat Genet 2012-10-09

...PIK3CA, the gene that encodes the p110α catalytic subunit of PI3K, only in affected cells. Sequencing of PIK3CA in ten a...

Lee(Jeong Ho),Huynh(My),Silhavy(Jennifer L... Nat Genet 2012-10-09

...PIK3CA, AKT3 and MTOR genes. A recurrent PIK3CA c.1633G>A mutation was found in four separate cases. Identified mutation...

Rivière(Jean-Baptiste),Mirzaa(Ghayda M),O'... Nat Genet 2012-10-09

...PIK3CA in 23 individuals with MCAP and 1 with MPPH. Our data highlight the central role of PI3K-AKT signaling in vascula...

Pelosi(Giuseppe),Gasparini(Patrizia),Cavaz... Lung Cancer 2012-12-21

...PIK3CA mutations were assessed by direct sequencing, ALK, EGFR and HER2 gene status by fluorescence in situ hybridizatio...

Kwon(Mi Jung),Lee(Seung Eun),Kang(So Young... Pathol Res Pract 2012-04-09

KRAS, BRAF, and PIK3CA mutation testing before administration of anti-epidermal growth factor receptor therapy of metast...

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