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PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to alloste...

Meric-Bernstam(Funda),Akcakanat(Argun),Che... Clin Cancer Res 2012-06-28

...PIK3CA and/or PTEN mutations were more likely to be RS (P = 0.0123). Akt phosphorylation (S473 and T308) was significant...

Assessment of colorectal cancer molecular features along bowel subsites chall...

Yamauchi(Mai),Morikawa(Teppei),Kuchiba(Aya... Gut 2012-07-13

...PIK3CA mutations) were examined along bowel subsites (rectum, rectosigmoid junction, sigmoid, descending colon, splenic ...

Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.

Liao(Xiaoyun),Lochhead(Paul),Nishihara(Rei... N Engl J Med 2012-11-13

...PIK3CA colorectal cancer, but not among patients with wild-type PIK3CA cancer. The findings from this molecular patholog...

Comprehensive molecular portraits of human breast tumours.

Nature 2012-11-26

...PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated ...

Angiogenic alterations associated with circulating neoplastic DNA in ovarian ...

Vogel(Tilley Jenkins),Dellorusso(Christian... Transl Oncol 2012-10-02

...PIK3CA, HIF1A, IL8, MMP2, and MMP9 message by real-time quantitative polymerase chain reaction. The expression of each g...

Identification of new candidate therapeutic target genes in triple-negative b...

Glénisson(Mathilde),Vacher(Sophie),Callens... Genes Cancer 2012-08-23

...PIK3CA mutation status. These results confirm the interest of targeting VEGFA and PARP1 in ongoing clinical trials in TN...

Identification of molecular pathway aberrations in uterine serous carcinoma b...

Kuhn(Elisabetta),Wu(Ren-Chin),Guan(Bin),Wu... J Natl Cancer Inst 2012-12-10

...PIK3CA mutation and/or PIK3CA amplification.,Molecular genetic aberrations involving the p53, cyclin E-FBXW7, and PI3K p...

High-resolution melting analysis as a sensitive prescreening diagnostic tool ...

Ney(Jasmin Teresa),Froehner(Stefanie),Roes... Arch Pathol Lab Med 2012-11-30

...PIK3CA and AKT1 genes are promising therapeutic targets in breast cancer. In 60% to 70% of malignant melanomas, a mutati...

Detection of PIK3CA Mutations in Breast Cancer Bone Metastases.

Daneshmand(Manijeh),Hanson(Jennifer E L),N... ISRN Oncol 2012-09-13

...PIK3CA status in their bone metastases. For each of these, the PIK3CA mutation status was the same in the primary and me...

Resequencing analysis of the candidate tyrosine kinase and RAS pathway gene f...

Hucthagowder(Vishwanathan),Meyer(Rekha),Mu... Cancer Genet 2012-12-14

...PIK3CA, INSR, LTK, and MERTK genes. In particular, seven novel mutations in addition to known KRAS mutations were observ...

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