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The association of PI3 kinase signaling and chemoresistance in advanced ovari...

Carden(Craig P),Stewart(Adam),Thavasu(Para... Mol Cancer Ther 2012-10-31

...PIK3CA and AKT, were sequenced by PCR-amplified mass spectroscopy detection methods. In addition, PIK3CA and AKT2 amplif...

Use of mutation profiles to refine the classification of endometrial carcinomas.

McConechy(Melissa K),Ding(Jiarui),Cheang(M... J Pathol 2012-10-09

...PIK3CA, KRAS, CTNNB1, TP53, BRAF, and PPP2R5C. Based on this gene panel, each endometrial carcinoma subtype shows a dist...

Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in pat...

Ikeda(Yuji),Oda(Katsutoshi),Nakagawa(Shuns... Int J Gynecol Cancer 2012-10-16

...PIK3CA, PTEN, K-Ras, and CTNNB1.,Of the 5 patients, 3 exhibited identical CNA patterns, including type, loci, and degree...

Hotspot oncomutations: implications for personalized cancer treatment.

Myers(Meagan B),Wang(Yiying),McKim(Karen L... Expert Rev Mol Diagn 2012-12-07

...PIK3CA) show that these tumor mutations have predictive power for identifying which patients are likely to respond to pa...

Novel small interfering RNA cotargeting strategy as treatment for colorectal ...

Valentino(Joseph D),Elliott(Victoria A),Za... Surgery 2012-10-01

...PIK3CA and KRAS small interfering RNAs were most effective as single treatments; combined treatments with PIK3CA and KRA...

The molecular pathogenesis of head and neck squamous cell carcinoma.

Rothenberg(S Michael),Ellisen(Leif W) J Clin Invest 2012-08-20

...PIK3CA and RAS occur in HNSCC, they are relatively uncommon. Instead genetic data point to a contribution of multiple tu...

PIK3CA is critical for the proliferation, invasiveness, and drug resistance o...

Chen(Yu),Hou(Qingyi),Yan(Wangxiang),Luo(Ji... Oncol Res 2012-08-07

...PIK3CA mutation is correlated with the aggressiveness of many epithelial cancers. And so PIK3CA is considered as a major...

Comprehensive molecular characterization of human colon and rectal cancer.

Nature 2012-08-17

...PIK3CA and KRAS mutations, we found frequent mutations in ARID1A, SOX9 and FAM123B. Recurrent copy-number alterations in...

Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhi...

Huang(Wen-Sheng),Wang(Tian-Bao),He(Yao),Ch... World J Gastroenterol 2012-12-06

...PIK3CA)-targeted double-stranded RNA (dsRNA) and its effect on cell proliferation and cycle distribution in SW948.,Two P...

Mutational analysis of PIK3CA, JAK2, BRAF, FOXL2, IDH1, AKT1 and EZH2 oncogen...

Je(Eun M),An(Chang H),Yoo(Nam J),Lee(Sug H... APMIS 2012-11-21

...PIK3CA (exons 9 and 20), JAK2 (exon 14), BRAF (exon 15), FOXL2 (exon 1), IDH1 (exon 4), AKT1 (exon 3), and EZH2 (exon 16...

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