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Activation of the PI3K/AKT pathway in Merkel cell carcinoma.

Hafner(Christian),Houben(Roland),Baeurle(A... PLoS One 2012-06-29

...PIK3CA and AKT1 mutations. Oncogenic PIK3CA mutations were found in 2/46 (4%) MCCs whereas mutations in exon 4 of AKT1 w...

Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and lit...

Liao(Xiaoyun),Morikawa(Teppei),Lochhead(Pa... Clin Cancer Res 2012-08-31

...PIK3CA exon 9 and 20 mutations might confer aggressive tumor behavior.,We sequenced PIK3CA by pyrosequencing in 1,170 re...

Low frequency of PIK3CA gene mutations in hepatocellular carcinoma in Chinese...

Li(Xun),Zhang(Quanbao),He(Wenting),Meng(We... Pathol Oncol Res 2012-06-18

...PIK3CA gene missense mutations have been reported in many human cancer types. The mutation of it in hepatocellular carci...

Altered composition of fatty acids exacerbates hepatotumorigenesis during act...

Kudo(Yotaro),Tanaka(Yasuo),Tateishi(Keisuk... J Hepatol 2012-04-05

...Pik3ca transgenic (Tg) mice harboring N1068fs*4 mutation.,The Tg mice exhibited hepatic steatosis and tumor development....

Optimization of patient selection for EGFR-TKIs in advanced non-small cell l...

Ludovini(V),Bianconi(F),Pistola(L),Pistola... Cancer Chemother Pharmacol 2012-06-18

We present a comprehensive analysis of KRAS, PIK3CA, MET, and non-sensitizing EGFR mutations in advanced non-small cell ...

Novel mutations of the HRAS gene and absence of hotspot mutations of ...

Koumaki(Dimitra),Kostakis(George),Koumaki(... Oncol Rep 2012-07-23

...PIK3CA gene mutations in the Greek population, we hypothesized that BRAF or HRAS may be activated as upstrea...

Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, a...

Davies(Barry R),Greenwood(Hannah),Dudley(P... Mol Cancer Ther 2012-10-16

...PIK3CA and/or PTEN mutations and sensitivity to AZD5363 and between RAS mutations and resistance. Oral dosing of AZD5363...

Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human...

Jiao(Xiang),Wood(Laura D),Lindman(Monica),... Genes Chromosomes Cancer 2012-07-16

...PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved.

New insights on the pathogenesis of ovarian carcinoma: molecular basis and cl...

Gadducci(Angiolo),Guerrieri(Maria Elena),G... Gynecol Endocrinol 2012-12-10

...PIK3CA and ARID1A. Type II tumours, accounting for 75% of the cases, have a very aggressive biological behaviour, are us...

[PIK3CA mutation is an independent indicator of malignant phenotype and progn...

Li(Shao-Ying),Wang(Wei),Li(Jian-Mei),Wang(... Zhonghua Zhong Liu Za Zhi 2012-11-26

...PIK3CA) occur in a variety of cancer types. The purpose of this study was to determine the relationship between PIK3CA m...

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