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Clinical outcomes and molecular profile of differentiated thyroid cancers wit...

Sabra(M M),Dominguez(J M),Grewal(R K),Lars... J Clin Endocrinol Metab 2013-07-05

...PIK3CA mutations were found in 42, 23, 10, and 2% of tumors, respectively, and the remaining 23% were wild type. None of...

Coexistent mutations of KRAS and PIK3CA affect the efficacy of NVP-BEZ235, a ...

Kim(Areumnuri),Lee(Jung-Eun),Lee(Seung-Soo... Int J Cancer 2013-08-12

...PIK3CA mutations show activation of AKT and MTOR, particularly when KRAS and PIK3CA mutations coexist. Suppression of PI...

Complex tumor genomes inferred from single circulating tumor cells by array-C...

Heitzer(Ellen),Auer(Martina),Gasch(Christi... Cancer Res 2013-07-22

...PIK3CA] found in the primary tumor and metastasis were also detected in corresponding CTCs. However, we also observed mu...

PTEN, Akt, MAPK, p53 and p95 expression to predict trastuzumab resistance in ...

Duman(B B),Sahin(B),Acikalin(A),Ergin(M),Z... J BUON 2013-06-26

...PIK3CA oncogene and inhibit the tumor suppressor gene PTEN action are commonly found in breast tumors. Akt is a key acti...

Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients tr...

Cizkova(M),Dujaric(M-E),Lehmann-Che(J),Sco... Br J Cancer 2013-07-15

...PIK3CA gene, encoding one of the two PI3K subunits.,PIK3CA mutations were assessed by direct sequencing in 80 HER2-posit...

Complete genomic landscape of a recurring sporadic parathyroid carcinoma.

Kasaian(Katayoon),Wiseman(Sam M),Thiessen(... J Pathol 2013-08-27

...PIK3CA. Comparison of acquired mutations in patient-matched primary and recurrent tumours revealed loss of PIK3CA activa...

Mutational analyses of epidermal growth factor receptor and downstream pathwa...

Hermsen(Ilse G C),Haak(Harm R),de Krijger(... Eur J Endocrinol 2013-07-15

...PIK3CA or KRAS, mutations were found. No relationship was found between mutation status, immunostaining and mitotane res...

Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associ...

Tornesello(Maria Lina),Buonaguro(Luigi),Ta... Genomics 2013-12-27

...PIK3CA (exon 9) genes in HCC from Southern Italy. The overall mutation frequency of TP53 and CTNNB1 was 33.3%, while hot...

Targeted agents in non-small cell lung cancer therapy: What is there on the h...

Villaflor(Victoria M),Salgia(Ravi) J Carcinog 2013-04-22

...PIK3CA. ROS-1, RET Fibroblast growth factor receptor (FGFR). Ephrins and their receptors, BRAF, and immunotherapies/vacc...

mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.

Deming(Dustin A),Leystra(Alyssa A),Farhoud... PLoS One 2013-10-22

...PIK3ca). The cancers in these mice are moderately differentiated invasive mucinous adenocarcinomas of the proximal colon...

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