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Validation of the Cancer BioChip System as a 3D siRNA screening tool for brea...

Marhefka(Joie N),Abbud-Antaki(Rula A) PLoS One 2013-04-10

...PIK3CA) siRNA. Interestingly, we have observed responses to siRNA that are unique to this 3D setting. For example, ß-act...

The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer.

Slomovitz(Brian M),Coleman(Robert L) Clin Cancer Res 2013-06-11

...PIK3CA may be indicators of sensitivity to PI3K/AKT/mTOR pathway inhibition, while activating KRAS mutations may predict...

Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progre...

Piana(Simonetta),Ragazzi(Moira),Tallini(Gi... Hum Pathol 2013-05-07

...PIK3CA [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed. Interestingly, all 3 cases presented w...

PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling...

Janku(Filip),Wheler(Jennifer J),Naing(Aung... Cancer Res 2013-02-27

...PIK3CA H1047R mutation compared with patients who had other PIK3CA mutations or patients with wild-type PIK3CA treated o...

KRAS mutation testing in metastatic colorectal cancer.

Tan(Cong),Du(Xiang) World J Gastroenterol 2013-03-28

...PIK3CA and loss of PTEN proposed by many researchers and pathologists, should be promoted. In addition, we recommend tha...

Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses.

Le(Long P),Dias-Santagata(Dora),Pawlak(Ama... PLoS One 2013-05-31

...PIK3CA, and TP53 on 54 cases of apocrine-eccrine carcinomas. They include 10 apocrine carcinomas, 7 eccrine carcinomas, ...

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic ...

Berglund(F M),Weerasinghe(N R),Davidson(L)... Oncogene 2013-11-08

Genetic changes in HER2, PTEN, PIK3CA and AKT1 are all common in breast cancer and lead to the elevated phosphorylation ...

Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent ...

Gökmen-Polar(Yesim),Liu(Yi),Toroni(Rachel ... Breast Cancer Res Treat 2013-06-11

...PIK3CA mutations. MLN0128 potently inhibited cell proliferation in various breast cancer cell lines harboring PIK3CA (IC...

Topoisomerase II alpha gene amplification is a favorable prognostic factor in...

Fountzilas(George),Christodoulou(Christos)... J Transl Med 2013-04-01

...PIK3CA mutations were identified by single nucleotide polymorphism genotyping. Survival was evaluated from the initiatio...

Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resista...

Chandarlapaty(Sarat),Sakr(Rita A),Giri(Dil... Clin Cancer Res 2013-05-28

...PIK3CA in 13 (29%). The combined rate of PTEN loss and PIK3CA mutation in the trastuzumab-refractory tumors was 71% comp...

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