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Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wil...

Seymour(Matthew T),Brown(Sarah R),Middleto... Lancet Oncol 2013-09-09

...PIK3CA mutations, and predefined molecular subgroups were analysed for interaction with the effect of panitumumab. This ...

EGFR L2 domain mutation is not correlated with resistance to cetuximab in met...

Ito(Yuriko),Yamada(Yasuhide),Asada(Kiyoshi... J Cancer Res Clin Oncol 2013-09-17

...PIK3CA exon 20. The objective of the study is to study the impact of EGFR L2 mutations on resistance to cetuximab in KRA...

Traditional serrated adenoma of the colorectum: clinicopathologic implication...

Kim(Mi-Jung),Lee(Eun-Jung),Suh(Jung-Pil),C... Am J Clin Pathol 2013-12-31

...PIK3CA, and EGFR and immunohistochemical staining for Ki-67 were performed on 107 TSAs from 104 patients.,Nondysplastic ...

Acquired PIK3CA amplification causes resistance to selective phosphoinositide...

Huw(L-Y),O'Brien(C),Pandita(A),Mohan(S),Sp... Oncogenesis 2013-12-24

...PIK3CA mutant breast cancer cell line, KPL-4. We identified a heretofore-unreported mechanism of resistance, specificall...

Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and or...

Won(Hye Sung),Jung(Chan-Kwon),Chun(Sang Ho... Oral Oncol 2013-05-29

...PIK3CA, pAkt, mTOR, and PTEN was assessed by immunohistochemistry. In situ hybridization was used to detect the existenc...

Mutational analysis of cutaneous squamous cell carcinomas and verrucal kerato...

Anforth(Rachael),Tembe(Varsha),Blumetti(Ta... Pigment Cell Melanoma Res 2013-01-03

...PIK3CA in both verrucal keratosis and cuSCC. This suggests that verrucal keratosis is an early clinical presentation of ...

Analysis of driver mutations in female non-smoker Asian patients with pulmona...

Ren(Shengxiang),Kuang(Peng),Zheng(Limou),S... Cell Biochem Biophys 2013-03-04

...PIK3CA. 73 (70.2 %) tumors harbored EGFR mutations; among these, 28 were deletions in exon 19, 44 were L858R missense ch...

Molecular profiling of patients with colorectal cancer and matched targeted t...

Dienstmann(Rodrigo),Serpico(Danila),Rodon(... Mol Cancer Ther 2013-02-07

...PIK3CA mutations (15 of 114, 13.2%), KRAS and PIK3CA mutations (9 of 114, 7.9%), low PTEN expression (97 of 183, 53.0%),...

Phase II trial of temsirolimus in patients with metastatic breast cancer.

Fleming(Gini F),Ma(Cynthia X),Huo(Dezheng)... Breast Cancer Res Treat 2013-06-14

...PIK3CA mutations; no association was found between prolonged stable disease and PIK3CA mutation or any immunohistochemic...

Initiating breast cancer by PIK3CA mutation.

Miller(Todd W) Breast Cancer Res 2013-02-07

...PIK3CA in luminal mammary epithelial cells induces tumorigenesis, implying that PIK3CA mutation is an early event in bre...

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