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PIK3CA genotype and a PIK3CA mutation-related gene signature and response to ...

Loi(Sherene),Michiels(Stefan),Baselga(Jose... PLoS One 2013-08-20

...PIK3CA genotype as well as a previously reported PI3K/mTOR-pathway gene signature (PIK3CA-GS) and their ability to estim...

Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammar...

Koren(Shany),Bentires-Alj(Mohamed) FEBS J 2013-08-05

...PIK3CA, the gene encoding the catalytic subunit p110α of PI3K, is mutated in ~ 30% of breast cancers. However, the exact...

Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PI...

Gaikwad(Snehal M),Gunjal(Lata),Junutula(An... PLoS One 2013-08-26

...PIK3CA sensor in PA1 and A2780 cells exhibited attenuating activity without any change in SKOV3 tumors expressing the PI...

Total synthetic protoapigenone WYC02 inhibits cervical cancer cell proliferat...

Chen(Yun-Ju),Kay(Nari),Yang(Jinn-Moon),Lin... Basic Clin Pharmacol Toxico... 2013-11-26

...PIK3CA, PIK3CB, PIK3CD and PIK3CG. Indeed, WYC02 decreased the expression of PIK3 family proteins, especially PIK3CG, th...

New targetable oncogenes in non-small-cell lung cancer.

Oxnard(Geoffrey R),Binder(Adam),Jänne(Pasi A) J Clin Oncol 2013-05-15

...PIK3CA mutations, FGFR1 amplifications, DDR2 mutations, ROS1 rearrangements, and RET rearrangements. In this review, we ...

Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY29...

Yoshioka(Takashi),Yogosawa(Shingo),Yamada(... Gynecol Oncol 2013-06-11

...PIK3CA and PTEN. The present study aimed to examine the combined effect of a novel histone deacetylase (HDAC) inhibitor ...

Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oe...

Tebbutt(N C),Parry(M M),Zannino(D),Strickl... Br J Cancer 2013-04-23

...PIK3CA mutations were observed.,Cetuximab and docetaxel achieve modest responses rates, but maintain comparable survival...

Multiple genetic alterations within the PI3K pathway are responsible for AKT ...

De Marco(Carmela),Rinaldo(Nicola),Bruni(Pa... PLoS One 2013-09-06

...PIK3CA or KRAS genes were detected at lower frequency (12% and 10%, respectively) whereas mutations in AKT1 or AKT2 gene...

A phase 1 study of everolimus plus docetaxel plus cisplatin as induction chem...

Fury(Matthew G),Sherman(Eric),Ho(Alan L),X... Cancer 2013-07-01

...PIK3CA) gene mutations were identified in 2 human papillomavirus-associated oropharyngeal cancers.,The phase 2 recommend...

Gene mutations in squamous cell NSCLC: insignificance of EGFR, KRAS and PIK3C...

Fiala(Ondrej),Pesek(Milos),Finek(Jindrich)... Anticancer Res 2013-06-11

...PIK3CA mutations in 3.8% of patients. No correlation of EGFR or PIK3CA mutation status with progression-free survival (P...

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