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Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroi...

Ganly(Ian),Ricarte Filho(Julio),Eng(Stepha... J Clin Endocrinol Metab 2013-07-05

...PIK3CA, MAP2K1, and AKT1. In addition, common oncogenic fusions of RET and NTRK1 as well as PAX8/PPARγ and AKAP9-BRAF we...

Non-invasive analysis of acquired resistance to cancer therapy by sequencing ...

Murtaza(Muhammed),Dawson(Sarah-Jane),Tsui(... Nature 2013-06-25

...PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) following treatment with paclitaxel; a ...

New perspectives on molecular targeted therapy in ovarian clear cell carcinom...

Tan(D S P),Miller(R E),Kaye(S B) Br J Cancer 2013-07-15

...PIK3CA and inactivation of PTEN, and increased activity of pathways involved in angiogenesis. Targeting HER2, apoptotic ...

Mutation analysis of the EGFR gene and downstream signalling pathway in histo...

Mezzapelle(R),Miglio(U),Rena(O),Paganotti(... Br J Cancer 2013-07-15

...PIK3CA and BRAF gene mutations by direct sequencing.,Gene mutations were identified in nine cases (12%): five KRAS, thre...

Molecular determinants of trastuzumab efficacy: What is their clinical releva...

De(Pradip),Hasmann(Max),Leyland-Jones(Bria... Cancer Treat Rev 2013-10-28

...PIK3CA), loss of phosphatase and tensin homolog (PTEN), activation of other downstream signal transducers, prevention of...

Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, ...

Patel(Rajesh),Tsan(Alison),Tam(Rachel),Des... PLoS One 2013-06-17

...PIK3CA, NRAS, BRAF, and AKT1 oncogenes. The DNA was preamplified using custom-designed primer sets before the TaqMan/AS-...

Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR ...

Troiani(Teresa),Zappavigna(Silvia),Martine... Expert Opin Biol Ther 2013-06-19

...PIK3CA, loss of expression of PTEN and, now, activation of HER2 signaling through HER2 gene amplification and/or increas...

PIK3CA mutational status and overall survival in patients with cervical cance...

McIntyre(John B),Wu(Jackson S),Craighead(P... Gynecol Oncol 2013-06-24

...PIK3CA mutations in patients with cervical cancer treated with radical CRT and (2) to examine the effect of tumor PIK3CA...

Oncogenic driver mutations in patients with non-small-cell lung cancer at var...

Zhou(J X),Yang(H),Deng(Q),Gu(X),He(P),Lin(... Ann Oncol 2013-12-19

...PIK3CA mutations and 3 had MEK1 mutations. EML4-ALK, PIK3CA, and MEK1 mutations were mutually exclusive. EML4-ALK fusion...

High-throughput mutation profiling of primary and metastatic endometrial canc...

Krakstad(Camilla),Birkeland(Even),Seidel(D... PLoS One 2013-06-27

...PIK3CA were consistently the most frequently mutated genes in primary tumors, metastatic lesions and cell lines.,Our res...

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