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AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynam...

Yap(Timothy A),Walton(Mike I),Grimshaw(Kyl... Clin Cancer Res 2013-04-03

...PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer, and PTEN-deficient MES-SA uterine tumor xenografts...

Oncogenic mutations in extramammary Paget's disease and their clinical releva...

Kang(Zhihua),Xu(Feng),Zhang(Qiao-an),Wu(Zh... Int J Cancer 2013-02-20

...PIK3CA, AKT1, CTNNB1 and APC genes as well as methylation and expression of CDH1 in 144 EMPD cases and 42 matched normal...

Prospective, high-throughput molecular profiling of human gliomas.

Chi(Andrew S),Batchelor(Tracy T),Dias-Sant... J Neurooncol 2013-04-23

...PIK3CA closely matched frequencies reported in recent studies. In addition, we identified events that are rare in glioma...

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary ...

Murat(C B),Braga(P B S),Fortes(M A H Z),Br... Braz J Med Biol Res 2013-11-19

...PIK3CA mutation in one noninvasive corticotroph microadenoma. PIK3CA amplification was observed in 21.2% (7/33) of the c...

Loss of PTEN induces microtentacles through PI3K-independent activation of co...

Vitolo(M I),Boggs(A E),Whipple(R A),Yoon(J... Oncogene 2013-06-19

...PIK3CA mutants, we have further demonstrated that there are clear differences in activation of cofilin, LIMK and SSH bet...

Analysis of driver mutations in female non-smoker Asian patients with pulmona...

Ren(Shengxiang),Kuang(Peng),Zheng(Limou),S... Cell Biochem Biophys 2013-03-04

...PIK3CA. 73 (70.2 %) tumors harbored EGFR mutations; among these, 28 were deletions in exon 19, 44 were L858R missense ch...

The utility of diagnostic biopsy specimens for predictive molecular testing i...

Fadhil(Wakkas),Ibrahem(Salih),Seth(Rashmi)... Histopathology 2013-05-21

...PIK3CA (exons 1, 9, and 20), TP53 (exons 5-8), and microsatellite instability, using the quick multiplex consensus or st...

Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a m...

Lochhead(Paul),Imamura(Yu),Morikawa(Teppei... Eur J Cancer 2013-02-14

...PIK3CA mutations.,Among 671 colorectal cancers, 234 (35%) tumours were positive for IGF2BP3. In contrast, normal colorec...

Array CGH and PIK3CA/AKT1 mutations to drive patients to specific targeted ag...

Arnedos(M),Scott(V),Job(B),De La Cruz(J),C... Eur J Cancer 2013-03-07

Breast cancer includes high number of molecular entities targetable by specific agents. In this study, array CGH and PIK...

Gene network profiling before and after transplantation in alcoholic cirrhosi...

Muffak-Granero(K),Olmedo(C),Garcia-Alcalde... Transplant Proc 2013-01-03

...PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide); IFNGR2 (interferon gamma receptor 2); JAK2 (Janus Kina...

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