...PIK3CA, FZD2, CAMK2A, and RYR2 exhibited significant promoter hypomethylation together with increased mRNA expression. I...
...PIK3CA, and AKT1 as the major hub targets. GO and KEGG enrichment analyses suggested that these targets were primarily i...
...PIK3CA allele and TP53 deficiency. Using a CRISPR/Cas9 approach to delete PTX3 in TAb2 cells (PTX3-KO), we found that PT...
...PIK3CA hotspot mutations were detected in p16-negative, high-risk HPV-associated SCCs. In contrast, 2 HPV-independent SC...
...PIK3CA , and TBX3 mutations and depleted TP53 and MYC alterations relative to local breast cancers, with additional depl...
...PIK3CA mutations (p.E542K and p.E726K) together with a truncating CDH1 variant (p.Q383*). The variant allele frequency o...
...PIK3CA) inhibitor for severe manifestations of PIK3CA-related overgrowth spectrum, and inhibits upstream of sirolimus in...
...PIK3CA, with the PI3K-Akt pathway identified as the key. Molecular docking confirmed stable binding of the top five comp...
...PIK3CA with a limit of detection of 4% variant allele frequency (VAF). 1516 CRC patients underwent genomic profiling at ...
...PIK3CA, MET, and FGFR family members. Tumor areas were selectively collected to ensure high tumor purity. Mutations were...
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