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TP53 BRCA1 CRISPR single-cell cancer

Rios(Jonathan J),Paria(Nandina),Burns(Denn... Hum Mol Genet 2013-07-01

...PIK3CA (R115P) present in the patient's affected nerve tissue but not in blood DNA. Sequencing PIK3CA exons identified g...

Baxi(Sangita M),Tan(Wei),Murphy(Sean T),Sm... PLoS One 2013-04-12

...PIK3CA mutations, were most responsive to IGF-I induction resulting in upregulated AKT and p70S6K phosphorylation via PD...

Bozzao(Cristina),Varvara(Dora),Piglionica(... Int J Biol Markers 2013-09-05

...PIK3CA exon 20. The prevalence of BRAF and PIK3CA mutations was significantly higher in patients older than 65 years (p=...

Chandarlapaty(Sarat),Sakr(Rita A),Giri(Dil... Clin Cancer Res 2013-05-28

...PIK3CA in 13 (29%). The combined rate of PTEN loss and PIK3CA mutation in the trastuzumab-refractory tumors was 71% comp...

Fountzilas(George),Christodoulou(Christos)... J Transl Med 2013-04-01

...PIK3CA mutations were identified by single nucleotide polymorphism genotyping. Survival was evaluated from the initiatio...

Piana(Simonetta),Ragazzi(Moira),Tallini(Gi... Hum Pathol 2013-05-07

...PIK3CA [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed. Interestingly, all 3 cases presented w...

Slomovitz(Brian M),Coleman(Robert L) Clin Cancer Res 2013-06-11

...PIK3CA may be indicators of sensitivity to PI3K/AKT/mTOR pathway inhibition, while activating KRAS mutations may predict...

Berglund(F M),Weerasinghe(N R),Davidson(L)... Oncogene 2013-11-08

Genetic changes in HER2, PTEN, PIK3CA and AKT1 are all common in breast cancer and lead to the elevated phosphorylation ...

Gökmen-Polar(Yesim),Liu(Yi),Toroni(Rachel ... Breast Cancer Res Treat 2013-06-11

...PIK3CA mutations. MLN0128 potently inhibited cell proliferation in various breast cancer cell lines harboring PIK3CA (IC...

Janku(Filip),Wheler(Jennifer J),Naing(Aung... Cancer Res 2013-02-27

...PIK3CA H1047R mutation compared with patients who had other PIK3CA mutations or patients with wild-type PIK3CA treated o...

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