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TP53 BRCA1 CRISPR single-cell cancer

Bowles(D W),Ma(W W),Senzer(N),Brahmer(J R)... Br J Cancer 2013-11-15

...PIK3CA-MUT/KRAS-WT vs PIK3CA-WT/KRAS-WT was observed.,Treatment with PX-866 and docetaxel was well tolerated, without ev...

Cimino(Daniela),De Pittà(Cristiano),Orso(F... FASEB J 2013-04-26

...PIK3CA/p110α, and NRAS, as well as CSF1, a growth factor for stroma cells. Our findings reveal the importance of the ide...

Sukawa(Yasutaka),Yamamoto(Hiroyuki),Nosho(... World J Gastroenterol 2013-12-12

...PIK3CA mutation, R88Q and R108H, were found in exon1. All PIK3CA mutations were heterozygous missense single-base substi...

Matias-Guiu(Xavier),Prat(Jaime) Histopathology 2013-06-13

...PIK3CA, K-RAS and CTNNB1 (beta-catenin), type II exhibits TP53 mutations and chromosomal instability. Recent investigati...

Iyengar(Sunil),Clear(Andrew),Bödör(Csaba),... Blood 2013-05-16

...PIK3CA and PIK3R1 mutations were absent. Although p110δ inhibition was sufficient to block B-cell receptor-mediated PI3K...

Wang(Haofei),Wu(Hua),Cai(Kaican),Ju(Qun),W... J BUON 2013-04-24

...PIK3CA copy number: 47 tumors with a PIK-3CA deletion had a mean Ki67 of 16, while 103 tumors with PIK3CA amplification ...

Lorenz(Sybille),Lissewski(Christina),Simse... Hum Mol Genet 2013-09-03

...PIK3CA, indicating a compromised association between active HRAS(E63_D69dup) and PIK3CA. Accordingly, overexpression of ...

Groesser(Leopold),Herschberger(Eva),Sagrer... J Invest Dermatol 2013-10-17

...PIK3CA, and BRAF mutations using SNaPshot assays and Sanger sequencing. We identified a heterozygous HRAS c.37G>C (p.Gly...

Kisiel(J B),Yab(T C),Nazer Hussain(F T),Ta... Aliment Pharmacol Ther 2013-07-18

...PIK3CA genes were insufficiently informative, but several aberrantly methylated genes were highly discriminant. In the s...

Flatley(Ellen),Ang(Daphne),Warrick(Andrea)... Hum Pathol 2013-08-20

...PIK3CA (encoding phosphatidylinositol-3-kinase catalytic subunit) or AKT1 are found in 25% to 30% of invasive ductal car...

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