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TP53 BRCA1 CRISPR single-cell cancer

Sabra(M M),Dominguez(J M),Grewal(R K),Lars... J Clin Endocrinol Metab 2013-07-05

...PIK3CA mutations were found in 42, 23, 10, and 2% of tumors, respectively, and the remaining 23% were wild type. None of...

Zhao(Siming),Choi(Murim),Overton(John D),B... Proc Natl Acad Sci U S A 2013-04-26

...PIK3CA, ERBB2 (an upstream activator of PIK3CA), and CCNE1 (a target of FBXW7-mediated ubiquitination). These findings i...

Raina(Komal),Agarwal(Chapla),Wadhwa(Ritamb... Autophagy 2013-11-22

...PIK3CA-AKT-MTOR but activated MAP2K1/2-MAPK1/3 pathways for its biological effects. Corroborating these effects, endopla...

Ang(Daphne),O'Gara(Rebecca),Schilling(Amy)... J Mol Diagn 2013-12-04

...PIK3CA. We tested 60 FFPE breast DNA samples with known PIK3CA mutation status (48 cases had one or more PIK3CA mutation...

Wik(Elisabeth),Birkeland(Even),Trovik(Jone... Clin Cancer Res 2013-11-12

...PIK3CA copy number (FISH) and a PI3K activation score (all P < 0.05).,High pStathmin(S38) is a novel biomarker of increa...

Yang(Fen),Qian(Xiao-Jun),Qin(Wei),Deng(Ron... PLoS One 2013-09-11

...PIK3CA mutation, compared to cells with wild-type PIK3CA. Furthermore, exposure of NPC cells to NVP-BEZ235 resulted in G...

Wu(Shuangjie),Gan(Yu),Wang(Xinhai),Liu(Jun... J Cancer Res Clin Oncol 2013-06-21

PIK3CA mutation appears to predict a lack of response to anti-EGFR monoclonal antibody (mAb) treatment in patients with ...

Voss(Jesse S),Holtegaard(Leonard M),Kerr(S... Hum Pathol 2013-08-20

...PIK3CA (n = 5), MET (n = 4), EGFR (n = 1), BRAF (n = 2), and NRAS (n = 1). Mutations were identified in 7 (26%) of 27 ex...

Yip(Po Yee),Yu(Bing),Cooper(Wendy A),Selin... J Thorac Oncol 2013-09-12

...PIK3CA, ALK, PDGFRA, AKT1, BRAF, FGFR1, and HRAS mutations were detected in tumors from 77 (37.7%), 29 (14.2%), 9 (4.4%)...

Bradshaw-Pierce(Erica L),Pitts(Todd M),Kul... PLoS One 2013-09-10

...PIK3CA mutant HT29 tumor xenografts, which had an additive effect, than the KRAS/PIK3CA mutant HCT116 tumor xenografts, ...

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