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Mutational profiling of bone metastases from lung adenocarcinoma: results of ...

Confavreux(Cyrille B),Girard(Nicolas),Pial... Bonekey Rep 2014-10-20

...PIK3CA, HER2 and ALK) were obtained in 41/45 (91%) of cases. A mutation was observed in 50% of cases including 32% of KR...

Colorectal cancer in Chinese patients: current and emerging treatment options...

Li(Leung),Ma(Brigette By) Onco Targets Ther 2014-10-22

...PIK3CA, ERCC1) in Chinese populations. Interethnic differences in anticancer drug response and toxicity have been well d...

Combined Antiangiogenic and Mammalian Target of Rapamycin Inhibitor Targeted ...

Agarwal(Rishi),Koenig(Kimberly),Rohren(Eri... J Breast Cancer 2014-10-16

...PIK3CA mutation in codon 545, exon 10 (GAG to AAG; p.Glu545Lys) and a TP53 mutation in codon 286, exon 8 (GAA to AAA; p....

Integrative and comparative genomic analysis of lung squamous cell carcinomas...

Kim(Youngwook),Hammerman(Peter S),Kim(Jaeg... J Clin Oncol 2014-03-03

...PIK3CA). Comparative analysis between Korean and North American lung SCC samples demonstrated a similar spectrum of alte...

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combi...

Hare(Lauren M),Phesse(Toby J),Waring(Paul ... Biochem J 2014-04-07

...Pik3caH1047R mutation, the most common PIK3CA mutation in CRC, during the development and progression of intestinal canc...

Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-depen...

Salt(Megan B),Bandyopadhyay(Sourav),McCorm... Cancer Discov 2014-09-30

...PIK3CA expression is upregulated in mesenchymal tumors with low levels of ERBB3. This study defines how ERBB3 downregula...

Role of the PI3K/AKT pathway in modulating cytoskeleton rearrangements and ph...

Fan(Zhiyu),Li(Chunyu),Qin(Chaoyi),Xie(Lian... DNA Cell Biol 2014-03-03

...PIK3CA-adenovirus induced cytoskeleton rearrangements and downregulated SM22α and α-SM actin gene expression. Inhibition...

Integrated molecular portrait of non-small cell lung cancers.

Lazar(Vladimir),Suo(Chen),Orear(Cedric),va... BMC Med Genomics 2014-06-25

...PIK3CA, SOX2, THPO, TP63, PDGFB genes. Gene expression profiling analysis identified SPP1, CTHRC1 and GREM1 as potential...

PIK3CA gene mutations and amplifications in Chinese patients with ovarian cle...

Jiang(Gaofeng),Huang(Zhixiong),Zhang(Shuan... Cancer Invest 2014-02-07

...PIK3CA in 51 Chinese OCCC patients. Activating missense mutations of PIK3CA were found in nine (17.6%) cases. One novel ...

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like br...

Tilch(E),Seidens(T),Cocciardi(S),Reid(L E)... Breast Cancer Res Treat 2014-08-28

...PIK3CA gene (18/107, 16.8 %), while mutations in KRAS, NRAS, MET and AKT1 were present in only one tumour each (1/107, 0...

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