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Cancer therapy. Ex vivo culture of circulating breast tumor cells for individ...

Yu(Min),Bardia(Aditya),Aceto(Nicola),Bersa... Science 2014-08-06

...PIK3CA gene and newly acquired mutations in the estrogen receptor gene (ESR1), PIK3CA gene, and fibroblast growth factor...

Next-generation sequencing reveals frequent consistent genomic alterations in...

Ross(J S),Wang(K),Elkadi(O R),Tarasen(A),F... J Clin Pathol 2014-12-12

...PIK3CA (6%), EGFR (5%), PTEN (5%), KRAS (5%), MCL1 (4%), FGFR1 (4%), BRCA2, (4%), TSC1 (3%), NF1 (3%), EPHA3 (3%) and CC...

Mutational analysis of merkel cell carcinoma.

Erstad(Derek J),Jr(James C Cusack) Cancers (Basel) 2014-10-21

...PIK3CA, have been documented in subsets of patients. Other mechanisms are also likely at play, including infection with ...

Mutational profiling of bone metastases from lung adenocarcinoma: results of ...

Confavreux(Cyrille B),Girard(Nicolas),Pial... Bonekey Rep 2014-10-20

...PIK3CA, HER2 and ALK) were obtained in 41/45 (91%) of cases. A mutation was observed in 50% of cases including 32% of KR...

Influence of CHIEF pathway genes on gene expression: a pathway approach to fu...

Slattery(Martha L),Lundgreen(Abbie),Mullan... Int J Mol Epidemiol Genet 2014-06-24

...PIK3CA, and RPS6KB2; RPS6KB1 rs80711475 with STK11 expression; STK11 rs741765 with PIK3CA and PRKAG2 expression; and TSC...

Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refrac...

Takalkar(Amol),Adams(Scott),Subbiah(Vivek) Exp Hematol Oncol 2014-09-22

...PIK3CA mutation (p.His1047Arg) positive presented with diffuse bony metastases and bone pain. She had hormone refractory...

Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purifi...

Neves(Rui P L),Raba(Katharina),Schmidt(Oli... Clin Chem 2014-11-24

...PIK3CA) gene and exons 5, 7, and 8 of the tumor protein p53 (TP53) gene.,One common flow-sorting protocol was appropriat...

Boolean ErbB network reconstructions and perturbation simulations reveal indi...

von der Heyde(Silvia),Bender(Christian),He... BMC Syst Biol 2014-09-22

...PIK3CA-mutation, contributing to trastuzumab inefficacy. Drug impact on the AKT and ERK1/2 signalling axes is mirrored b...

Integrated RNA and DNA sequencing improves mutation detection in low purity t...

Wilkerson(Matthew D),Cabanski(Christopher ... Nucleic Acids Res 2014-10-14

...PIK3CA, ERBB2 and FGFR2). In summary, integrating RNA-seq with DNA-WES increases mutation detection performance, especia...

Phase II trial of cetuximab plus irinotecan for oxaliplatin- and irinotecan-b...

Soeda(Hiroshi),Shimodaira(Hideki),Gamoh(Ma... Oncology 2014-09-03

...PIK3CA, NRAS, and AKT1 mutation status. The clinical outcome after the treatment was evaluated for each mutation status....

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